Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Nucleotides are required for a wide variety of biological processes and are constantly
synthesized de novo in all cells. When cells proliferate, increased nucleotide synthesis is …

Introduction Metabolomics is a well-established tool in systems biology, especially in the top–
down approach. Metabolomics experiments often results in discovery studies that provide …

Metabolomics is based on cutting-edge analytical methods that provide a “snapshot” of all
the detectable metabolites, small molecules generally weighing under 1200 Da, present in …

Understanding the mechanisms of the Warburg shift to aerobic glycolysis is critical to
defining the metabolic basis of cancer. Hereditary leiomyomatosis and renal cell carcinoma …

Abstract The Apolipoprotein E (APOE) gene is a major genetic risk factor associated with
Alzheimer's disease (AD). APOE encodes for three main isoforms in humans (E2, E3, and …

Introduction Lung cancer continues to be the leading cause of cancer-related mortality
worldwide. Early detection has proven essential to extend survival. Genomic and proteomic …

Iron–sulfur (Fe-S) clusters are ancient cofactors in cells and participate in diverse
biochemical functions, including electron transfer and enzymatic catalysis. Although cell …

Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive
to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable …

Introduction Stable isotope tracers have been increasingly used in preclinical cancer model
systems, including cell culture and mouse xenografts, to probe the altered metabolism of a …