Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally
intractable and is suspected to be the result of recurrent excitation or inhibition circuitry …

The epilepsies are common neurologic disorders characterized by spontaneous recurrent
seizures. Boys, girls, men, and women of all ages are affected by epilepsy and, in many …

Whether long febrile seizures (FSs) can cause epilepsy in the absence of genetic or
acquired predisposing factors is unclear. Having established causality between long FSs …

Experimental prolonged febrile seizures (FS) lead to structural and molecular changes that
promote hippocampal hyperexcitability and reduce seizure threshold to further convulsants …

The mechanisms that transform a normal brain to an epileptic one are not fully understood.
Interleukin-1 beta (IL-1β) contributes to neuronal degeneration observed in several …

Seizures induced by fever (febrile seizures) are the most common type of pathological brain
activity in infants and children. These febrile seizures and their potential contribution to the …

Studies of febrile seizures have been driven by two major enigmas: first, how these most
common of human seizures are generated by fever has not been known. Second …

Seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been
observed nearly universally in experimental models of limbic epilepsy and in the epileptic …

The extent that status epilepticus (SE), but also brief seizures, affects neuronal structure and
function has been the subject of much clinical and experimental research. There is a …

Mesial temporal sclerosis probably has different causes. A number of retrospective studies
showed that complex febrile seizures are a causative factor for the later development of …