The most important enteric virus infecting canids is canine parvovirus type 2 (CPV-2). CPV is
the aetiologic agent of a contagious disease, mainly characterized by clinical gastroenteritis …

Parvoviruses, infecting vertebrates and invertebrates, are a family of single-stranded DNA
viruses with small, non-enveloped capsids with T= 1 icosahedral symmetry. A quarter of a …

The structure of the adeno-associated virus (AAV-2) has been determined to 3-Å resolution
by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat …

Adeno-associated virus type 2 (AAV2) has proven to be a valuable vector for gene therapy.
Characterization of the functional domains of the AAV capsid proteins can facilitate our …

Canine parvovirus (CPV) is a host range variant of a feline virus that acquired the ability to
infect dogs through changes in its capsid protein. Canine and feline viruses both use the …

Background: The structure of simian virus 40 (SV40), previously determined at 3.8 å
resolution, shows how its pentameric VP1 assembly units are tied together by extended C …

Transfer of viruses between hosts to create a new self-sustaining epidemic is rare; however,
those new viruses can cause severe outbreaks. Examples of such viruses include three …

The human parvovirus adeno-associated virus type 2 (AAV-2) possesses many features that
make it an attractive vector for gene delivery in vivo. However, its broad host range may limit …

Adeno-associated virus type 2 (AAV2) capsids show 12 pores at the fivefold axes of
symmetry. We mutated amino acids which constitute these pores to investigate possible …

The past few years have seen major advances in our understanding of the controls of
evolution, host range and cell tropism of parvoviruses. Notable findings have included the …