Quantification of microglial activation through morphometric analysis has long been a staple
of the neuroimmunologist's toolkit. Microglial morphological phenomics can be conducted …

Background Microglia are the tissue-resident macrophages of the CNS. They originate in the
yolk sac, colonize the CNS during embryonic development and form a self-sustaining …

As an endogenous activator of toll-like receptor-4 (Tlr4), the extracellular matrix glycoprotein
tenascin-C (TnC) regulates chemotaxis, phagocytosis and proinflammatory cytokine …

Background Stroke remains one of the leading causes of long-term disability worldwide, and
the development of effective restorative therapies is hindered by an incomplete …

Sepsis predisposes for poor stroke outcome. This association suggests that sepsis disturbs
post-ischemic tissue survival and brain remodeling. To elucidate this link, we herein …

Introduction Develo** effective treatment for Alzheimer's disease (AD) remains a
challenge. This can be partially attributed to the fact that the mouse models used in …

We recently reported exacerbated endotoxic signs of neuroinflammation and autonomic
defects in offspring of preeclamptic (PE) dams. Here, we investigated whether PE …

Infection is a major reason for poor stroke outcomes, and sepsis is a major cause of stroke-
elated deaths. We herein examined whether NMDA receptor blockade, which was reported …

Maternal deprivation (MD) is known to be related to long‐term changes that could influence
the onset of psychiatric disorders. Studies have demonstrated that early life stress makes the …

Introduction: Preeclampsia (PE) enhances the vulnerability of adult offspring to serious
illnesses. The current study investigated whether preeclamptic fetal programming impacts …