Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation
T Liu, W **ang, Z Chen, G Wang, R Cao, F Zhou… - Cell Death & …, 2023 - nature.com
Clear cell renal cell carcinoma (ccRCC) is a type of kidney cancer that is both common and
aggressive, with a rising incidence in recent decades. Hypoxia is a key factor that plays a …
aggressive, with a rising incidence in recent decades. Hypoxia is a key factor that plays a …
The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …
[HTML][HTML] The Role of Adipocytes Recruited as Part of Tumor Microenvironment in Promoting Colorectal Cancer Metastases
Y Ma, M Nenkov, Y Chen, N Gaßler - International journal of molecular …, 2024 - mdpi.com
Adipose tissue dysfunction, which is associated with an increased risk of colorectal cancer
(CRC), is a significant factor in the pathophysiology of obesity. Obesity-related inflammation …
(CRC), is a significant factor in the pathophysiology of obesity. Obesity-related inflammation …
[HTML][HTML] TDERS, an exosome RNA-derived signature predicts prognosis and immunotherapeutic response in clear cell renal cell cancer: a multicohort study
A Jiang, Y Liu, Z He, W Liu, Q Yang, Y Fang… - Journal of the National …, 2024 - Elsevier
Background Tumor-derived exosomes are involved in tumor progression and immune
invasion and might function as promising noninvasive approaches for clinical management …
invasion and might function as promising noninvasive approaches for clinical management …
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
While hypoxic signaling has been shown to play a role in many cellular processes, its role in
metabolism-linked extracellular matrix (ECM) organization and downstream processes of …
metabolism-linked extracellular matrix (ECM) organization and downstream processes of …
Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer
G Frame, H Leong, R Haas, X Huang, J Wright… - BJC reports, 2024 - nature.com
Background Metastatic relapse of prostate cancer after radiotherapy is a significant cause of
prostate cancer-related morbidity and mortality. PLOD2 is a mediator of invasion and …
prostate cancer-related morbidity and mortality. PLOD2 is a mediator of invasion and …
Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma
Q Liu, J Wang, H Sun, Z Zhang, H Wang, S Ma… - Molecular Therapy, 2024 - cell.com
Approximately 80%–90% of hepatocellular carcinomas (HCC) occur in a premalignant
environment of fibrosis and abnormal extracellular matrix (ECM), highlighting an essential …
environment of fibrosis and abnormal extracellular matrix (ECM), highlighting an essential …
[HTML][HTML] The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy
The tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …
physiological activities under aerobic conditions. Although tumor metabolic reprogramming …
Hypoxia‐induced translation of collagen‐modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells
HH Li, HY Hung, JS Yu, YC Liao, MC Lai - The FEBS Journal, 2024 - Wiley Online Library
Hypoxia is a critical microenvironmental factor that induces tumorigenesis and cancer
progression, including metastasis. The highly dynamic nature of the extracellular matrix …
progression, including metastasis. The highly dynamic nature of the extracellular matrix …
Potential crosstalk between Naïve CD4+ T cells and SPP1+ Macrophages is associated with clinical outcome and therapeutic response in hepatocellular carcinoma
L Dong, X Qiu, Z Li, W Ge, X Tang, R Zhou… - International …, 2024 - Elsevier
Background The highly heterogeneity of the tumor microenvironment (TME) in
hepatocellular carcinoma (HCC) results in diverse clinical outcomes and therapeutic …
hepatocellular carcinoma (HCC) results in diverse clinical outcomes and therapeutic …