Oxidative stress refers to the imbalance between the production of reactive oxygen species
(ROS) and the endogenous antioxidant defense system. Its involvement in cell senescence …

Simple Summary The creation of a guideline of guidelines could help physicians apprehend
different approaches to malignancies and better-tailoring patients' management. In this …

Purpose: The purpose of this guideline is to provide a useful reference on the effective
evidence-based diagnoses and management of non-metastatic upper tract urothelial …

Background Optimal patient selection for neoadjuvant chemotherapy prior to surgical
extirpation is limited by the inaccuracy of contemporary clinical staging methods in high-risk …

Simple Summary As upper tract urothelial carcinoma is a relatively rare disease, much of
clinical practice has been extrapolated from urothelial carcinoma data. Here we summarize …

Bladder cancer (BC) is one of the most common malignancies in the United States, with over
80,000 new cases and 16,000 deaths each year. Urothelial carcinoma (UC) is the most …

Upper tract urothelial carcinoma (UTUC) is an aggressive and difficult malignancy to treat.
Owing to its rarity and the lack of specific high-level data, management mirrors that of …

The interplay between genetic alterations and metabolic dysregulation is increasingly
recognized as a pivotal axis in cancer pathogenesis. Both elements are mutually reinforcing …

Purpose: Little is known regarding the prognostic implications of variant histology in upper
tract urothelial carcinoma (UTUC). We sought to evaluate the impact of variant histology …

Purpose To assess the impact of neoadjuvant and adjuvant chemotherapy on survival
outcomes, within a large multicenter cohort of Upper tract urothelial carcinoma patients …