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Relaxin family peptides and their receptors
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …
many roles in female and male reproduction, as a neuropeptide in the central nervous …
Oxidative stress and renal fibrosis: recent insights for the development of novel therapeutic strategies
Chronic kidney disease (CKD) is a significant worldwide healthcare problem. Regardless of
the initial injury, renal fibrosis is the common final pathway leading to end stage renal …
the initial injury, renal fibrosis is the common final pathway leading to end stage renal …
Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis
Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood
vessels from an aberrant wound healing response to organ injury or insult. Established …
vessels from an aberrant wound healing response to organ injury or insult. Established …
Anti‐fibrotic actions of relaxin
Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant
wound healing in response to organ injury, and its manifestations in various organs have …
wound healing in response to organ injury, and its manifestations in various organs have …
Relaxin prevents cardiac fibroblast-myofibroblast transition via notch-1-mediated inhibition of TGF-β/Smad3 signaling
The hormone relaxin (RLX) is produced by the heart and has beneficial actions on the
cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal …
cardiovascular system. We previously demonstrated that RLX stimulates mouse neonatal …
International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …
Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …
[HTML][HTML] The involvement of the Wnt/β-catenin signaling cascade in fibrosis progression and its therapeutic targeting by relaxin
Organ scarring, referred to as fibrosis, results from a failed wound-healing response to
chronic tissue injury and is characterised by the aberrant accumulation of various …
chronic tissue injury and is characterised by the aberrant accumulation of various …
Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS
BSM Chow, EGY Chew, C Zhao, RAD Bathgate… - 2012 - journals.plos.org
The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition
by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide …
by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide …
The actions of relaxin on the human cardiovascular system
The insulin‐like peptide relaxin, originally identified as a hormone of pregnancy, is now
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
known to exert a range of pleiotropic effects including vasodilatory, anti‐fibrotic, angiogenic …
A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1
Human gene-2 relaxin (H2 relaxin) is a pleiotropic hormone with powerful vasodilatory and
anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval …
anti-fibrotic properties which has led to its clinical evaluation and provisional FDA approval …