Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer

T Sen, N Takahashi, S Chakraborty, N Takebe… - Nature Reviews …, 2024 - nature.com
Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a
dismal prognosis, with only modest advances in therapeutic strategies over the past several …

Small cells–big issues: biological implications and preclinical advancements in small cell lung cancer

A Solta, B Ernhofer, K Boettiger, Z Megyesfalvi… - Molecular cancer, 2024 - Springer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …

Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling

T El Zarif, CB Meador, X Qiu, JH Seo… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: Histologic transformation to small cell lung cancer (SCLC) is a mechanism of
treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma …

Small-cell lung cancer: is liquid biopsy a new tool able to predict the efficacy of immunotherapy?

R Fasano, S Serratì, T Rafaschieri, V Longo, R Di Fonte… - Biomolecules, 2024 - mdpi.com
Small-cell lung cancer (SCLC) cases represent approximately 15% of all lung cancer cases,
remaining a recalcitrant malignancy with poor survival and few treatment options. In the last …

[HTML][HTML] Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity

E Redin, Á Quintanal-Villalonga, CM Rudin - Trends in Cancer, 2024 - cell.com
Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …

Cell-free and extrachromosomal DNA profiling of small cell lung cancer

R Behrouzi, A Clipson, KL Simpson, F Blackhall… - Trends in molecular …, 2024 - cell.com
Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative
prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently …

Spatial transcriptome‐wide profiling of small cell lung cancer reveals intra‐tumoral molecular and subtype heterogeneity

Z Zhang, X Sun, Y Liu, Y Zhang, Z Yang… - Advanced …, 2024 - Wiley Online Library
Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid
growth and early metastasis and is susceptible to treatment resistance and recurrence …

Mining nucleic acid “omics” to boost liquid biopsy in cancer

A Tivey, RJ Lee, A Clipson, SM Hill, P Lorigan… - Cell Reports …, 2024 - cell.com
Treatments for cancer patients are becoming increasingly complex, and there is a growing
desire from clinicians and patients for biomarkers that can account for this complexity to …

Comprehensive review of reinforcement learning in lung cancer diagnosis and treatment: Taxonomy, challenges and recommendations

M Ghorbian, S Ghorbian - Computers in Biology and Medicine, 2024 - Elsevier
Lung cancer (LuC) is one of the leading causes of death in the world, and due to the
complex mechanisms and widespread metastasis, diagnosis and treatment are challenging …

Circulating tumor DNA in liquid biopsy: Current diagnostic limitation

SC Liu - World Journal of Gastroenterology, 2024 - pmc.ncbi.nlm.nih.gov
With the rapid development of science and technology, cell-free DNA (cfDNA) is rapidly
becoming an important biomarker for tumor diagnosis, monitoring and prognosis, and this …