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Emerging advances in defining the molecular and therapeutic landscape of small-cell lung cancer
Small-cell lung cancer (SCLC) has traditionally been considered a recalcitrant cancer with a
dismal prognosis, with only modest advances in therapeutic strategies over the past several …
dismal prognosis, with only modest advances in therapeutic strategies over the past several …
Small cells–big issues: biological implications and preclinical advancements in small cell lung cancer
A Solta, B Ernhofer, K Boettiger, Z Megyesfalvi… - Molecular cancer, 2024 - Springer
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …
human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises …
Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling
Purpose: Histologic transformation to small cell lung cancer (SCLC) is a mechanism of
treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma …
treatment resistance in patients with advanced oncogene-driven lung adenocarcinoma …
Small-cell lung cancer: is liquid biopsy a new tool able to predict the efficacy of immunotherapy?
Small-cell lung cancer (SCLC) cases represent approximately 15% of all lung cancer cases,
remaining a recalcitrant malignancy with poor survival and few treatment options. In the last …
remaining a recalcitrant malignancy with poor survival and few treatment options. In the last …
[HTML][HTML] Small cell lung cancer profiling: an updated synthesis of subtypes, vulnerabilities, and plasticity
Small cell lung cancer (SCLC) is a devastating disease with high proliferative and metastatic
capacity. SCLC has been classified into molecular subtypes based on differential …
capacity. SCLC has been classified into molecular subtypes based on differential …
Cell-free and extrachromosomal DNA profiling of small cell lung cancer
Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative
prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently …
prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently …
Spatial transcriptome‐wide profiling of small cell lung cancer reveals intra‐tumoral molecular and subtype heterogeneity
Z Zhang, X Sun, Y Liu, Y Zhang, Z Yang… - Advanced …, 2024 - Wiley Online Library
Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid
growth and early metastasis and is susceptible to treatment resistance and recurrence …
growth and early metastasis and is susceptible to treatment resistance and recurrence …
Mining nucleic acid “omics” to boost liquid biopsy in cancer
Treatments for cancer patients are becoming increasingly complex, and there is a growing
desire from clinicians and patients for biomarkers that can account for this complexity to …
desire from clinicians and patients for biomarkers that can account for this complexity to …
Comprehensive review of reinforcement learning in lung cancer diagnosis and treatment: Taxonomy, challenges and recommendations
Lung cancer (LuC) is one of the leading causes of death in the world, and due to the
complex mechanisms and widespread metastasis, diagnosis and treatment are challenging …
complex mechanisms and widespread metastasis, diagnosis and treatment are challenging …
Circulating tumor DNA in liquid biopsy: Current diagnostic limitation
SC Liu - World Journal of Gastroenterology, 2024 - pmc.ncbi.nlm.nih.gov
With the rapid development of science and technology, cell-free DNA (cfDNA) is rapidly
becoming an important biomarker for tumor diagnosis, monitoring and prognosis, and this …
becoming an important biomarker for tumor diagnosis, monitoring and prognosis, and this …