At present, bone nonunion and delayed union are still difficult problems in orthopaedics.
Since the discovery of bone morphogenetic protein (BMP), it has been widely used in …

The optimal balance between mechanical environment and biological factors is crucial for
successful bone healing, as they synergistically affect bone development. Any imbalance …

Purpose A healthy musculoskeletal system requires complex functional integration of bone,
muscle, cartilage, and connective tissues responsible for bodily support, motion, and the …

Many studies have explored different loading and rehabilitation strategies, yet rehabilitation
intensity and its impact on the local strain environment and bone healing have largely not …

Bone tissue engineering has emerged as a promising approach to addressing the
limitations of traditional bone grafts for repairing bone defects. This regenerative medicine …

Despite the glimmer of hope provided by the discovery and commercialization of bone
morphogenetic protein-2 (BMP-2) as a bone graft substitute, side effects related to the use of …

Unloading associated with spaceflight results in bone loss and increased fracture risk. Bone
morphogenetic protein 2 (BMP2) is known to enhance bone formation, in part, through …

Mechanical engineering, as a discipline, imbues a strong appreciation for how forces
influence the world around us. The combination of theoretical and practical training yield in …

Distraction osteogenesis, bone lengthening, is an established surgical technique for bone
lengthening. The procedure involves making osteotomies, in the bone, and using a device to …

The primary objective of this thesis was to quantify patient-specific loading and rehabilitation
parameters to elucidate how specific rehabilitation conditions impact bone healing after …