Vitamin B12 is an essential micronutrient required for optimal hemopoetic, neuro-cognitive
and cardiovascular function. Biochemical and clinical vitamin B12 deficiency has been …

Background and aims Metformin-treated type 2 diabetes mellitus (T2DM) patients are at
higher risk of vitamin B 12 deficiency and more severe neuropathy symptoms. There is still …

Metformin treatment is a known pharmacological cause of vitamin B12 (Cbl) deficiency with
controversial responsible mechanisms. A possible diagnosis of this deficiency is based …

Objective: To review the oral and injectable pharmacologic treatment options for type 2
diabetes. Data Sources: A literature search was conducted using PubMed electronic …

Materials and Methods: We recruited patients with Type 2 diabetes and divided them into
metformin exposed and nonmetformin exposed groups. We measured baseline …

Metformin is the first-choice drug in uncomplicated type 2 diabetes (T2DM) and is effective in
improving glycaemic control. It is the most widely prescribed oral antidiabetic medicine and …

AIM: The evidences illustrating the effects of folic acid supplementation (FAS) in individuals
with type 2 diabetes on plasma total homocysteine (tHcy) levels and glycemic control have …

Aims Metformin is associated with lowering of vitamin B12 levels. We hypothesise that
holotranscobalamin (holoTC) and methylmalonic acid (MMA) are more sensitive indicators …

Introduction Neuropathic pain is intense in nature and difficult to manage. Thus, the primary
goal is maximum relief from pain. The aim of this study was to assess the efficacy and safety …

Purpose Metformin is a common medication for patients with hyperglycemia. In adults, one
well-documented side effect of metformin is vitamin B12 deficiency. However, this side effect …