Common-and rare-variant genetic architecture of heart failure across the allele frequency spectrum

Human cardiac metabolism

MR Bornstein, R Tian, Z Arany - Cell Metabolism, 2024 - cell.com
The heart is the most metabolically active organ in the human body, and cardiac metabolism
has been studied for decades. However, the bulk of studies have focused on animal models …
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Genetic Biomarkers in Heart Failure: From Gene Panels to Polygenic Risk Scores

M Figueiral, A Paldino, L Fazzini, NL Pereira - Current heart failure reports, 2024 - Springer
Abstract Purpose of Review This review aims to provide a comprehensive overview of the
current understanding of genetic markers associated with heart failure (HF) and its …
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Connecting intermediate phenotypes to disease using multi-omics in heart failure

A Moore, R Venkatesh, MG Levin, SM Damrauer… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Heart failure (HF) is one of the most common, complex, heterogeneous diseases in the
world, with over 1–3% of the global population living with the condition. Progression of HF …
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