Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease

DK Sahoo, RM Heilmann, B Paital, A Patel… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal (GI) disorder
characterized by intestinal inflammation. The etiology of IBD is multifactorial and results from …

Neutrophils: from IBD to the gut microbiota

C Danne, J Skerniskyte, B Marteyn… - Nature Reviews …, 2024 - nature.com
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal
tract that results from dysfunction in innate and/or adaptive immune responses. Impaired …

An engineered butyrate-derived polymer nanoplatform as a mucosa-healing enhancer potentiates the therapeutic effect of magnolol in inflammatory bowel disease

X Fan, Z Zhang, W Gao, Q Pan, K Luo, B He, Y Pu - ACS nano, 2023 - ACS Publications
Colonic epithelial damage and dysregulated immune response are crucial factors in the
progression and exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted …

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

A Cuadrado, AI Rojo, G Wells, JD Hayes… - Nature reviews Drug …, 2019 - nature.com
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

Oxidative stress, inflammation, gut dysbiosis: what can polyphenols do in inflammatory bowel disease?

L Li, P Peng, N Ding, W Jia, C Huang, Y Tang - Antioxidants, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal
inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted and associated …

Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer

V Lazar, LM Ditu, GG Pircalabioru, I Gheorghe… - Frontiers in …, 2018 - frontiersin.org
The microbiota consists of a dynamic multispecies community of bacteria, fungi, archaea,
and protozoans, bringing to the host organism a dowry of cells and genes more numerous …

Reactive oxygen species‐activated CO versatile nanomedicine with innate gut immune and microbiome remodeling effects for treating inflammatory bowel disease

Y Zeng, M Fan, Q Zhou, D Chen, T **… - Advanced Functional …, 2023 - Wiley Online Library
Abnormal activation of the gut mucosal immune system and a highly dysregulated gut
microbiota play essential roles in the progression of inflammatory bowel disease (IBD). The …

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

M Xu, J Tao, Y Yang, S Tan, H Liu, J Jiang… - Cell Death & …, 2020 - nature.com
Ferroptosis has recently emerged as an iron-dependent form of nonapoptotic cell death,
which is also a regulated necrosis process and a response to tumor suppression. However …

Pathomechanisms of oxidative stress in inflammatory bowel disease and potential antioxidant therapies

T Tian, Z Wang, J Zhang - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has
risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an …