Insights into the post-translational modification and its emerging role in sha** the tumor microenvironment
More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …
tumors depend on gene mutation and tumor heterogeneity. The most important …
Metabolism, biochemical actions, and chemical synthesis of anticancer nucleosides, nucleotides, and base analogs
Nucleoside, nucleotide, and base analogs have been in the clinic for decades to treat both
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
viral pathogens and neoplasms. More than 20% of patients on anticancer chemotherapy …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …
CRISPR-mediated tagging of endogenous proteins with a luminescent peptide
Intracellular signaling pathways are mediated by changes in protein abundance and post-
translational modifications. A common approach for investigating signaling mechanisms and …
translational modifications. A common approach for investigating signaling mechanisms and …
Protein neddylation and its alterations in human cancers for targeted therapy
L Zhou, W Zhang, Y Sun, L Jia - Cellular signalling, 2018 - Elsevier
Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …
NRF2 activation in cancer: from DNA to protein
Abstract The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated
protein 1 and nuclear factor erythroid 2–related factor 2 (NRF2) signaling pathway in 6.3% of …
protein 1 and nuclear factor erythroid 2–related factor 2 (NRF2) signaling pathway in 6.3% of …
E1 enzymes as therapeutic targets in cancer
Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …
Cullin-RING Ligases as attractive anti-cancer targets
The ubiquitin-proteasome system (UPS) promotes the timely degradation of short-lived
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
proteins with key regulatory roles in a vast array of biological processes, such as cell cycle …
Targeting NEDD8-activating enzyme for cancer therapy: developments, clinical trials, challenges and future research directions
DJ Fu, T Wang - Journal of Hematology & Oncology, 2023 - Springer
NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …
Targeting lncRNA DDIT4‐AS1 sensitizes triple negative breast cancer to chemotherapy via suppressing of autophagy
T Jiang, J Zhu, S Jiang, Z Chen, P Xu… - Advanced …, 2023 - Wiley Online Library
In this study, it is found that the lncRNA, DNA damage inducible transcript 4 antisense RNA1
(DDIT4‐AS1), is highly expressed in triple‐negative breast cancer (TNBC) cell lines and …
(DDIT4‐AS1), is highly expressed in triple‐negative breast cancer (TNBC) cell lines and …