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Acquired immunity to malaria
Naturally acquired immunity to falciparum malaria protects millions of people routinely
exposed to Plasmodium falciparum infection from severe disease and death. There is no …
exposed to Plasmodium falciparum infection from severe disease and death. There is no …
The pathogenic basis of malaria
LH Miller, DI Baruch, K Marsh, OK Doumbo - Nature, 2002 - nature.com
Malaria is today a disease of poverty and underdeveloped countries. In Africa, mortality
remains high because there is limited access to treatment in the villages. We should follow …
remains high because there is limited access to treatment in the villages. We should follow …
How malaria has affected the human genome and what human genetics can teach us about malaria
DP Kwiatkowski - The American Journal of Human Genetics, 2005 - cell.com
Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …
selection in the recent history of the human genome. The past decade has seen growing …
The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
X Su, VM Heatwole, SP Wertheimer, F Guinet… - Cell, 1995 - cell.com
The human malaria parasite Plasmodium faiciparum evades host immunity by varying the
antigenic and adhesive character of infected erythrocytes. We describe a large and …
antigenic and adhesive character of infected erythrocytes. We describe a large and …
Severe falciparum malaria
World Health Organization - Transactions of the Royal Society of Tropical …, 2000 - Elsevier
A further meeting, sponsored by WHO, was held on 4-8 December 1995 in Geneva. The
purpose was to review in great detail the latest scientific evidence for, and practical …
purpose was to review in great detail the latest scientific evidence for, and practical …
Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
DI Baruch, BL Pasloske, HB Singh, X Bi, XC Ma… - Cell, 1995 - cell.com
Plasmodium falciparum-infected human erythrocytes evade host immunity by expression of
a ceil-surface variant antigen and receptors for adherence to endothelial cells. These …
a ceil-surface variant antigen and receptors for adherence to endothelial cells. These …
Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
Plasmodium falciparum expresses on the host erythrocyte surface clonally variant antigens
and ligands that mediate adherence to endothelial receptors. Both are central to …
and ligands that mediate adherence to endothelial receptors. Both are central to …
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season
CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …
endemic regions, where water availability limits mosquito vectors to only part of the year …
Malaria pathogenesis
LH Miller, MF Good, G Milon - Science, 1994 - science.org
Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the
erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human …
erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human …
Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
PC Bull, BS Lowe, M Kortok, CS Molyneux… - Nature medicine, 1998 - nature.com
The feasibility of a malaria vaccine is supported by the fact that children in endemic areas
develop naturally acquired immunity to disease. Development of disease immunity is …
develop naturally acquired immunity to disease. Development of disease immunity is …