Acquired immunity to malaria

DL Doolan, C Dobaño, JK Baird - Clinical microbiology reviews, 2009 - journals.asm.org
Naturally acquired immunity to falciparum malaria protects millions of people routinely
exposed to Plasmodium falciparum infection from severe disease and death. There is no …

The pathogenic basis of malaria

LH Miller, DI Baruch, K Marsh, OK Doumbo - Nature, 2002 - nature.com
Malaria is today a disease of poverty and underdeveloped countries. In Africa, mortality
remains high because there is limited access to treatment in the villages. We should follow …

How malaria has affected the human genome and what human genetics can teach us about malaria

DP Kwiatkowski - The American Journal of Human Genetics, 2005 - cell.com
Malaria is a major killer of children worldwide and the strongest known force for evolutionary
selection in the recent history of the human genome. The past decade has seen growing …

The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes

X Su, VM Heatwole, SP Wertheimer, F Guinet… - Cell, 1995 - cell.com
The human malaria parasite Plasmodium faiciparum evades host immunity by varying the
antigenic and adhesive character of infected erythrocytes. We describe a large and …

Severe falciparum malaria

World Health Organization - Transactions of the Royal Society of Tropical …, 2000 - Elsevier
A further meeting, sponsored by WHO, was held on 4-8 December 1995 in Geneva. The
purpose was to review in great detail the latest scientific evidence for, and practical …

Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes

DI Baruch, BL Pasloske, HB Singh, X Bi, XC Ma… - Cell, 1995 - cell.com
Plasmodium falciparum-infected human erythrocytes evade host immunity by expression of
a ceil-surface variant antigen and receptors for adherence to endothelial cells. These …

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

JD Smith, CE Chitnis, AG Craig, DJ Roberts… - Cell, 1995 - cell.com
Plasmodium falciparum expresses on the host erythrocyte surface clonally variant antigens
and ligands that mediate adherence to endothelial receptors. Both are central to …

Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

CM Andrade, H Fleckenstein, R Thomson-Luque… - Nature Medicine, 2020 - nature.com
The dry season is a major challenge for Plasmodium falciparum parasites in many malaria
endemic regions, where water availability limits mosquito vectors to only part of the year …

Malaria pathogenesis

LH Miller, MF Good, G Milon - Science, 1994 - science.org
Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the
erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human …

Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria

PC Bull, BS Lowe, M Kortok, CS Molyneux… - Nature medicine, 1998 - nature.com
The feasibility of a malaria vaccine is supported by the fact that children in endemic areas
develop naturally acquired immunity to disease. Development of disease immunity is …