The smallest viable unit of life is the cell. From bacteria to mammals, all cells use the same
nucleic acid-based universal code for the maintenance and inheritance of genetic …

The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …

Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby
eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and …

By phosphorylating elongation factors and the C-terminal domain of RNA polymerase II, the
positive transcription elongation factor b (P-TEFb) is the critical kinase for transcription …

NF-κB activates the primary inflammatory response pathway responsible for methicillin-
resistant Staphylococcus aureus (MRSA)-induced lung inflammation and injury. Here, we …

Over 60 bromodomains belonging to proteins with very different functions have been
identified in humans. Several of them interact with acetylated lysine residues, leading to the …

The association of DSIF and NELF with initiated RNA Polymerase II (Pol II) is the general
mechanism for inducing promoter-proximal pausing of Pol II. However, it remains largely …

Activation of the IκB kinase (IKK) complex has recurrently been linked to colorectal cancer
(CRC) initiation and progression. However, identification of downstream effectors other than …

The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active
genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery …

Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively
linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology …