Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …

Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

The N-ethylmaleimide-sensitive fusion protein (NSF) and the soluble NSF attachment
proteins (SNAPs) appear to be essential components of the intracellular membrane fusion …

Using a selection for spontaneous mutants that mislocalize a vacuolar carboxypeptidase Y
(CPY)-invertase fusion protein to the cell surface, we identified vacuolar protein targeting …

Aptamers are single-stranded nucleic acid molecules that possess properties comparable to
those of protein monoclonal antibodies, and thus are clear alternatives to long established …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

The fungal vacuole is an extremely complex organelle that is involved in a wide variety of
functions. The vacuole not only carries out degradative processes, the role most often …

Protein secretion from cells can take several forms. Secretion is constitutive if proteins are
secreted as fast as they are synthesized. In regulated secretion newly synthesized proteins …

Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

A vesicular intermediate in protein transport from the endopiasmic reticulum is detected in a
subset of temperature-sensitive mutants blocked early in the yeast secretory pathway. By …