Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

The RNA modification N 6-methyladenosine (m6A) has critical roles in many biological
processes,. However, the function of m6A in the early phase of mammalian development …

The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

We recently derived mouse expanded potential stem cells (EPSCs) from individual
blastomeres by inhibiting the critical molecular pathways that predispose their differentiation …

Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …

Classic embryological experiments have established that the early mouse embryo develops
via sequential lineage bifurcations. The first segregated lineage is the trophectoderm …

DNA methylation is a repressive epigenetic modification that is essential for development,
exemplified by the embryonic and perinatal lethality observed in mice lacking de novo DNA …

Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …