Adult epilepsy

AA Asadi-Pooya, F Brigo, S Lattanzi, I Blumcke - The Lancet, 2023‏ - thelancet.com
Epilepsy is a common medical condition that affects people of all ages, races, social classes,
and geographical regions. Diagnosis of epilepsy remains clinical, and ancillary …

Drug resistance in epilepsy

E Perucca, P Perucca, HS White, EC Wirrell - The Lancet Neurology, 2023‏ - thelancet.com
Drug resistance is estimated to affect about a third of individuals with epilepsy, but its
prevalence differs in relation to the epilepsy syndrome, the cause of epilepsy, and other …

International League Against Epilepsy classification and definition of epilepsy syndromes with onset in childhood: Position paper by the ILAE Task Force on Nosology …

N Specchio, EC Wirrell, IE Scheffer, R Nabbout… - …, 2022‏ - Wiley Online Library
Abstract The 2017 International League Against Epilepsy classification has defined a three‐
tier system with epilepsy syndrome identification at the third level. Although a syndrome …

International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on …

K Riney, A Bogacz, E Somerville, E Hirsch… - …, 2022‏ - Wiley Online Library
The goal of this paper is to provide updated diagnostic criteria for the epilepsy syndromes
that have a variable age of onset, based on expert consensus of the International League …

Methodology for classification and definition of epilepsy syndromes with list of syndromes: report of the ILAE Task Force on Nosology and Definitions

EC Wirrell, R Nabbout, IE Scheffer, T Alsaadi… - …, 2022‏ - Wiley Online Library
Epilepsy syndromes have been recognized for> 50 years, as distinct electroclinical
phenotypes with therapeutic and prognostic implications. Nonetheless, no formally accepted …

Developmental and epileptic encephalopathies

IE Scheffer, S Zuberi, HC Mefford, R Guerrini… - Nature Reviews …, 2024‏ - nature.com
Developmental and epileptic encephalopathies, the most severe group of epilepsies, are
characterized by seizures and frequent epileptiform activity associated with developmental …

Astrocytes as a target for therapeutic strategies in epilepsy: current insights

N Çarçak, F Onat, E Sitnikova - Frontiers in molecular neuroscience, 2023‏ - frontiersin.org
Astrocytes are specialized non-neuronal glial cells of the central nervous system,
contributing to neuronal excitability and synaptic transmission (gliotransmission). Astrocytes …

Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference

F **ao, L Caciagli, B Wandschneider, D Sone… - Brain, 2023‏ - academic.oup.com
Artificial intelligence (AI)-based tools are widely employed, but their use for diagnosis and
prognosis of neurological disorders is still evolving. Here we analyse a cross-sectional …

Utility of exome sequencing for diagnosis in unexplained pediatric-onset epilepsy

HY Koh, L Smith, KN Wiltrout, A Podury… - JAMA network …, 2023‏ - jamanetwork.com
Importance Genomic advances inform our understanding of epilepsy and can be translated
to patients as precision diagnoses that influence clinical treatment, prognosis, and …

[HTML][HTML] Complexity in genetic epilepsies: a comprehensive review

C Rastin, LC Schenkel, B Sadikovic - International journal of molecular …, 2023‏ - mdpi.com
Epilepsy is a highly prevalent neurological disorder, affecting between 5–8 per 1000
individuals and is associated with a lifetime risk of up to 3%. In addition to high incidence …