Innate immunity and the actions of type I and III interferons (IFNs) are essential for protection
from SARS-CoV-2 and COVID-19. Each is induced in response to infection and serves to …

Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to
possess antiviral functions similar to those of type I interferon, both of which are induced via …

Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …

IFNs are comprised of three families of cytokines that confer protection against pathogen
infection and uncontrolled cellular proliferation. The broad role IFNs play in innate and …

Tissue damage and repair are hallmarks of inflammation. Despite a wealth of information on
the mechanisms that govern tissue damage, mechanistic insight into how inflammation …

Prophylaxis for and treatment of graft-versus-host disease (GVHD) are essential for
successful allogeneic hematopoietic stem cell transplantation (allo-SCT) and mainly consist …

Despite advances in immunosuppressive prophylaxis and overall supportive care,
gastrointestinal (GI) graft-versus-host disease (GVHD) remains a major, lethal side effect …

Serving as the guardians of small intestine, Paneth cells (PCs) play an important role in
intestinal homeostasis maintenance. Although PCs uniquely exist in intestine under …

Interferon (IFN) was discovered based on interference with virus production, and three types
of IFN are now defined. Since its discovery, IFN's roles have expanded beyond viruses to …

Graft-vs-host disease (GVHD) is the most common cause of non-relapse mortality following
allogeneic hematopoietic stem cell transplantation (HSCT) despite advances in conditioning …