The biology of NKT cells

A Bendelac, PB Savage, L Teyton - Annu. Rev. Immunol., 2007 - annualreviews.org
Recognized more than a decade ago, NKT cells differentiate from mainstream thymic
precursors through instructive signals emanating during TCR engagement by CD1d …

[PDF][PDF] The liver as an immunological organ

V Racanelli, B Rehermann - Hepatology, 2006 - Wiley Online Library
The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

CD1: antigen presentation and T cell function

M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

NKT cells promote Th1 immune bias to dengue virus that governs long-term protective antibody dynamics

Y Choi, WAA Saron, A O'Neill, M Senanayake… - The Journal of Clinical …, 2024 - jci.org
NKT cells are innate-like T cells, recruited to the skin during viral infection, yet their
contributions to long-term immune memory to viruses are unclear. We identified granzyme K …

Going both ways: immune regulation via CD1d-dependent NKT cells

DI Godfrey, M Kronenberg - The Journal of clinical investigation, 2004 - jci.org
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

M Brigl, L Bry, SC Kent, JE Gumperz, MB Brenner - Nature immunology, 2003 - nature.com
CD1d-restricted natural killer T (NKT) cells are important for host defense against a variety of
microbial pathogens. How and when these T cells become activated physiologically during …

The unique role of natural killer T cells in the response to microorganisms

E Tupin, Y Kinjo, M Kronenberg - Nature Reviews Microbiology, 2007 - nature.com
Natural killer T (NKT) cells combine features of the innate and adaptive immune systems.
Recently, it has become evident that these T cells have crucial roles in the response to …

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans

C De Santo, M Salio, SH Masri, LYH Lee, T Dong… - The Journal of clinical …, 2008 - jci.org
Infection with influenza A virus (IAV) presents a substantial threat to public health worldwide,
with young, elderly, and immunodeficient individuals being particularly susceptible …

Increased intratumor Vα24-positive natural killer T cells: a prognostic factor for primary colorectal carcinomas

T Tachibana, H Onodera, T Tsuruyama… - Clinical Cancer …, 2005 - aacrjournals.org
Purpose: Human invariant natural killer T (NKT) cells are novel, distinct lymphocyte
populations with a restricted T-cell receptor repertoire (Vα24-Vβ11). They play a pivotal role …

The role of NKT cells in tumor immunity

M Terabe, JA Berzofsky - Advances in cancer research, 2008 - Elsevier
NKT cells are a relatively newly recognized member of the immune community, with
profound effects on the rest of the immune system despite their small numbers. They are true …