Copper signalling: causes and consequences
Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …
[HTML][HTML] The application of X-ray fluorescence microscopy and micro-XANES spectroscopy to study neuro-metallomics
This early career research highlight provides a review of my own research program over the
last decade, a time frame that encompasses my transition from postdoctoral fellowships to …
last decade, a time frame that encompasses my transition from postdoctoral fellowships to …
A multimodal spectroscopic imaging method to characterize the metal and macromolecular content of proteinaceous aggregates (“amyloid plaques”)
Alzheimer's disease (AD) is a major international health and economic concern. A key
pathological feature of AD is so-called “amyloid-β-plaques”, or “Aβ-plaques”, which are …
pathological feature of AD is so-called “amyloid-β-plaques”, or “Aβ-plaques”, which are …
Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental map**
Transition metal ions (Fe, Mn, Cu, Zn) are essential for healthy brain function, but altered
concentration, distribution, or chemical form of the metal ions has been implicated in …
concentration, distribution, or chemical form of the metal ions has been implicated in …
Maternal immune activation during pregnancy alters the behavior profile of female offspring of Sprague Dawley rats
Sex differences are documented in psychiatric and neurological disorders, yet most
preclinical animal research has been conducted in males only. There is a need to better …
preclinical animal research has been conducted in males only. There is a need to better …
Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus
A unique combination of sensitivity, resolution, and penetration make X-ray fluorescence
imaging (XFI) ideally suited to investigate trace elemental distributions in the biological …
imaging (XFI) ideally suited to investigate trace elemental distributions in the biological …
Subventricular Accumulation of Cu in the Aging Mouse Brain Does Not Associate with Anticipated Increases in Markers of Oxidative Stress
Natural aging is associated with mild memory loss and cognitive decline, and age is the
greatest risk factor for neurodegenerative diseases, such as Alzheimer's disease. There is …
greatest risk factor for neurodegenerative diseases, such as Alzheimer's disease. There is …
Biospectroscopic imaging provides evidence of hippocampal Zn deficiency and decreased lipid unsaturation in an accelerated aging mouse model
Western society is facing a health epidemic due to the increasing incidence of dementia in
aging populations, and there are still few effective diagnostic methods, minimal treatment …
aging populations, and there are still few effective diagnostic methods, minimal treatment …
Elemental Map** in a Preclinical Animal Model Reveals White Matter Copper Elevation in the Acute Phase of Central Nervous System Trauma
Understanding the chemical events following trauma to the central nervous system could
assist in identifying causative mechanisms and potential interventions to protect neural …
assist in identifying causative mechanisms and potential interventions to protect neural …
Characterising murine hippocampal iron homeostasis, in relation to markers of brain inflammation and metabolism, during ageing
Abstract Metal ions (Fe, Cu, and Zn) are essential to a healthy brain function, with the
amount, localisation, and chemical form often tightly controlled. Evidence points towards …
amount, localisation, and chemical form often tightly controlled. Evidence points towards …