Mitochondria are essential for tumor growth and progression. However, the heavy demand
for mitochondrial activity in cancer leads to increased production of mitochondrial reactive …

The majority of proteins localised to mitochondria are encoded by the nuclear genome, with
approximately 1500 proteins imported into mammalian mitochondria. Dysfunction in this …

HSP70 and HSP90 are two powerful chaperone machineries involved in survival and
proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 …

Mitochondria are required for cellular survival, yet can also orchestrate cell death. The
peculiar biochemical properties of these organelles, which are intimately linked to their …

The crosstalk between different organelles allows for the exchange of proteins, lipids and
ions. Endoplasmic reticulum (ER) and mitochondria are physically linked and signal through …

Mitochondria play a key role in cellular functions, including energy production and oxidative
stress regulation. For this reason, maintaining mitochondrial homeostasis and proteostasis …

In eukaryotic cells, organelles could coordinate complex mechanisms of signaling
transduction metabolism and gene expression through their functional interactions. The …

Mortalin was first cloned as a mortality factor that existed in the cytoplasmic fractions of
normal, but not in immortal, mouse fibroblasts. A decade of efforts have expanded its …

Since their discovery, heat shock proteins (HSPs) have been identified in all domains of life,
which demonstrates their importance and conserved functional role in maintaining protein …

The heat shock chaperones mortalin/mitochondrial heat shock protein 70 (mtHsp70) and
Hsp60 are found in multiple subcellular sites and function in the folding and intracellular …