High-altitude illnesses (HAIs) result from acute exposure to high altitude/hypoxia. Numerous
molecular mechanisms affect appropriate acclimatization to hypobaric and/or normobaric …

Oxygen is vital for cellular metabolism; therefore, the hypoxic conditions encountered at high
altitude affect all physiological functions. Acute hypoxia activates the adrenergic system and …

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

The pulmonary circulation is a high flow and low pressure circuit, with an average resistance
of 1 mmHg. min. L− 1 in young adults, increasing to 2.5 mmHg. min. L− 1 over 4–6 decades …

In the healthy, untrained young adult, a case is made for a respiratory system (airways,
pulmonary vasculature, lung parenchyma, respiratory muscles, and neural ventilatory …

High-altitude pulmonary edema (HAPE) is an uncommon form of pulmonary edema that
occurs in healthy individuals within a few days of arrival at altitudes above 2,500–3,000 m …

Endothelin receptor antagonists for pulmonary arterial hypertension - Liu, C - 2021 | Cochrane
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The global industrialization has brought profound lifestyle changes and environmental
pollutions leading to higher risks of cardiovascular diseases. Such tremendous challenges …

We address adaptive vs. maladaptive responses to hypoxemia in healthy humans and
hypoxic-tolerant species during wakefulness, sleep, and exercise. Types of hypoxemia …

Hypoxic pulmonary vasoconstriction (HPV) serves to optimize ventilation–perfusion
matching in focal hypoxia and thereby enhances pulmonary gas exchange. During global …