Systemic sclerosis (SSc; scleroderma) has the highest individual mortality of all rheumatic
diseases, and interstitial lung disease (ILD) is among the leading causes of SSc‐related …

Challenges for the effective management of interstitial lung diseases (ILDs) include
difficulties with the early detection of disease, accurate prognostication with baseline data …

Background 12 months of oral cyclophosphamide has been shown to alter the progression
of scleroderma-related interstitial lung disease when compared with placebo. However …

Objective Tocilizumab (TCZ) has demonstrated lung function preservation in 2 randomized
controlled trials in early systemic sclerosis (SSc). This effect has yet to be characterized in …

Background Based on international diagnostic guidelines, high-resolution CT plays a central
part in the diagnosis of fibrotic lung disease. In the correct clinical context, when high …

Background Connective tissue growth factor (CTGF) is a secreted glycoprotein that has a
central role in the process of fibrosis. This study was designed to assess the safety …

Rationale: Reliable outcome prediction in patients with fibrotic lung disease using baseline
high-resolution computed tomography (HRCT) data remains challenging. Objectives: To …

Objectives The objective of this study is to assess the performance of a computer-aided
diagnosis (CAD) system (INTACT system) for the automatic classification of high-resolution …

Purpose To evaluate associations between pulmonary function and both quantitative
analysis and visual assessment of thin-section computed tomography (CT) images at …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a rare and progressive disease that causes
progressive cough, exertional dyspnea, impaired quality of life, and death. Objectives …