There is increasing appreciation that non-neuronal cells contribute to the initiation,
progression and pathology of diverse neurodegenerative disorders. This Review focuses on …

Develo** diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to
study human brain development, evolution and disease. However, it is unclear which parts …

Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

Patient-derived organoids (PDOs) have emerged as a promising platform for clinical and
translational studies. A strong correlation exists between clinical outcomes and the use of …

The molecular diversity of glia in the human hippocampus and their temporal dynamics over
the lifespan remain largely unknown. Here, we performed single-nucleus RNA sequencing …

Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …