Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches
Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …
How is precursor messenger RNA spliced by the spliceosome?
Splicing of the precursor messenger RNA, involving intron removal and exon ligation, is
mediated by the spliceosome. Together with biochemical and genetic investigations of the …
mediated by the spliceosome. Together with biochemical and genetic investigations of the …
Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition
JM Izquierdo, N Majós, S Bonnal, C Martínez… - Molecular cell, 2005 - cell.com
Fas exon 6 can be included or skipped to generate mRNAs encoding, respectively, a
membrane bound form of the receptor that promotes apoptosis or a soluble isoform that …
membrane bound form of the receptor that promotes apoptosis or a soluble isoform that …
RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts
Ninety-four percent of mammalian protein-coding exons exceed 51 nucleotides (nt) in
length. The paucity of micro-exons (≤ 51 nt) suggests that their recognition and correct …
length. The paucity of micro-exons (≤ 51 nt) suggests that their recognition and correct …
Human branch point consensus sequence is yUnAy
K Gao, A Masuda, T Matsuura, K Ohno - Nucleic acids research, 2008 - academic.oup.com
Yeast carries a strictly conserved branch point sequence (BPS) of UACUA AC, whereas the
human BPS is degenerative and is less well characterized. The human consensus BPS has …
human BPS is degenerative and is less well characterized. The human consensus BPS has …
Fox-1 family of RNA-binding proteins
H Kuroyanagi - Cellular and Molecular Life Sciences, 2009 - Springer
The Fox-1 family of RNA-binding proteins are evolutionarily conserved regulators of tissue-
specific alternative splicing in metazoans. The Fox-1 family specifically recognizes the (U) …
specific alternative splicing in metazoans. The Fox-1 family specifically recognizes the (U) …
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes
Introns are among the hallmarks of eukaryotic genes. Splicing of introns is directed by three
main splicing signals: the 5′ splice site (5′ ss), the branch site (BS), and the …
main splicing signals: the 5′ splice site (5′ ss), the branch site (BS), and the …
Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome
S Sharma, LA Kohlstaedt, A Damianov… - Nature structural & …, 2008 - nature.com
The polypyrimidine tract binding protein (PTB) binds pre-mRNAs to alter splice-site choice.
We characterized a series of spliceosomal complexes that assemble on a pre-mRNA under …
We characterized a series of spliceosomal complexes that assemble on a pre-mRNA under …
[HTML][HTML] RNA-binding proteins: splicing factors and disease
AM Fredericks, KJ Cygan, BA Brown, WG Fairbrother - Biomolecules, 2015 - mdpi.com
Pre-mRNA splicing is mediated by interactions of the Core Spliceosome and an array of
accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory …
accessory RNA binding proteins with cis-sequence elements. Splicing is a major regulatory …
Role of viral splicing elements and cellular RNA binding proteins in regulation of HIV-1 alternative RNA splicing
CM Stoltzfus, JM Madsen - Current HIV research, 2006 - ingentaconnect.com
In HIV-1 infected cells, over 40 different mRNA species are produced by alternative splicing
of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 …
of the single HIV-1 primary RNA transcript. In addition, approximately half of the HIV-1 …