Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Since the discovery of eukaryotic small RNAs as the main effectors of RNA interference in
the late 1990s, diverse types of endogenous small RNAs have been characterized, most …

Germ cells are the only cells in the body capable of giving rise to a new organism, and this
totipotency hinges on their ability to assemble membraneless germ granules. These …

Germ granules are membrane-less organelles essential for small RNA biogenesis and
germline development. Among the conserved properties of germ granules is their …

The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

Highlights•Examples of transgenerational epigenetic inheritance of brain related
phenotypes.•Overview of putative molecular carriers of non-genetic information are …

Germ granules are non-membrane bound, phase-separated organelles, composed of RNAs
and proteins. Germ granules are present only within the germ cells of animals, including …

Germ granules are biomolecular condensates present in most animal germ cells. One
function of germ granules is to help maintain germ cell totipotency by organizing mRNA …

For decades, it was thought that the only heritable information transmitted from one
individual to another was that encoded in the DNA sequence. However, it has become …

Inherited information is transmitted to progeny primarily by the genome through the gametes.
However, in recent years, epigenetic inheritance has been demonstrated in several …