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Endothelial to Mesenchymal Transition in Cardiovascular Disease: JACC State-of-the-Art Review
Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …
undergoes a series of molecular events that lead to a change in phenotype toward a …
Endothelial to mesenchymal transition in health and disease
The endothelium is one of the largest organ systems in the body, and data continue to
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and …
Aortic valve stenosis: from basic mechanisms to novel therapeutic targets
Aortic valve stenosis is the most prevalent heart valve disease worldwide. Although
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
interventional treatment options have rapidly improved in recent years, symptomatic aortic …
[HTML][HTML] Cathepsin S (CTSS) activity in health and disease-A treasure trove of untapped clinical potential
P Smyth, J Sasiwachirangkul, R Williams… - Molecular aspects of …, 2022 - Elsevier
Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …
particular interest due to distinctive properties including a normal restricted expression …
Effect of denosumab or alendronic acid on the progression of aortic stenosis: a double-blind randomized controlled trial
Background: Valvular calcification is central to the pathogenesis and progression of aortic
stenosis, with preclinical and observational studies suggesting that bone turnover and …
stenosis, with preclinical and observational studies suggesting that bone turnover and …
Spatiotemporal multi-omics map** generates a molecular atlas of the aortic valve and reveals networks driving disease
Background: No pharmacological therapy exists for calcific aortic valve disease (CAVD),
which confers a dismal prognosis without invasive valve replacement. The search for …
which confers a dismal prognosis without invasive valve replacement. The search for …
LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification
C Yu, L Li, F **e, S Guo, F Liu, N Dong… - Cardiovascular …, 2018 - academic.oup.com
Aims Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a vital role in
cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in …
cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in …
Identification of immune-associated genes in diagnosing aortic valve calcification with metabolic syndrome by integrated bioinformatics analysis and machine learning
Y Zhou, W Shi, D Zhao, S **ao, K Wang… - Frontiers in …, 2022 - frontiersin.org
Background Immune system dysregulation plays a critical role in aortic valve calcification
(AVC) and metabolic syndrome (MS) pathogenesis. The study aimed to identify pivotal …
(AVC) and metabolic syndrome (MS) pathogenesis. The study aimed to identify pivotal …
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1
F Hadji, MC Boulanger, SP Guay, N Gaudreault… - Circulation, 2016 - ahajournals.org
Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery
Cardiovascular calcification is a health disorder with increasing prevalence and high
morbidity and mortality. The only available therapeutic options for calcific vascular and …
morbidity and mortality. The only available therapeutic options for calcific vascular and …