Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

The integration of cancer biomarkers into oncology has revolutionized cancer treatment,
yielding remarkable advancements in cancer therapeutics and the prognosis of cancer …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …

Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite
recent advancements, most patients die of their disease. Although immune checkpoint …

Total tumor clearance through immunotherapy is associated with a fully coordinated innate
and adaptive immune response, but knowledge on the exact contribution of each immune …

With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many
cancers, managing their immune-related adverse events (irAEs) has become an important …

Despite being an integral part of the immune response in the tumor microenvironment
(TME), few studies have mechanistically elucidated eosinophil functions in cancer …

Immune checkpoint inhibition (ICI) with chemotherapy is now the standard of care for stage II–
III triple-negative breast cancer; however, it is largely unknown for which patients ICI without …

Estrogens regulate eosinophilia in asthma and other inflammatory diseases. Further,
peripheral eosinophilia and tumor-associated tissue eosinophilia (TATE) predicts a better …