[HTML][HTML] The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …
Endocytosis in cancer and cancer therapy
Endocytosis is a complex process whereby cell surface proteins, lipids and fluid from the
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
extracellular environment are packaged, sorted and internalized into cells. Endocytosis is …
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial
YL Verschoor, J van de Haar, JG van den Berg… - Nature medicine, 2024 - nature.com
Gastric and gastroesophageal junction (G/GEJ) cancers carry a poor prognosis, and despite
recent advancements, most patients die of their disease. Although immune checkpoint …
recent advancements, most patients die of their disease. Although immune checkpoint …
Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial
Immune checkpoint inhibition (ICI) with chemotherapy is now the standard of care for stage II–
III triple-negative breast cancer; however, it is largely unknown for which patients ICI without …
III triple-negative breast cancer; however, it is largely unknown for which patients ICI without …
Clinical and translational attributes of immune-related adverse events
With immune checkpoint inhibitors (ICIs) becoming the mainstay of treatment for many
cancers, managing their immune-related adverse events (irAEs) has become an important …
cancers, managing their immune-related adverse events (irAEs) has become an important …
Estrogen signaling suppresses tumor-associated tissue eosinophilia to promote breast tumor growth
S Artham, PK Juras, A Goyal, P Chakraborty… - Science …, 2024 - science.org
Estrogens regulate eosinophilia in asthma and other inflammatory diseases. Further,
peripheral eosinophilia and tumor-associated tissue eosinophilia (TATE) predicts a better …
peripheral eosinophilia and tumor-associated tissue eosinophilia (TATE) predicts a better …
Eosinophils in the tumor microenvironment: implications for cancer immunotherapy
Despite being an integral part of the immune response in the tumor microenvironment
(TME), few studies have mechanistically elucidated eosinophil functions in cancer …
(TME), few studies have mechanistically elucidated eosinophil functions in cancer …
Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease
Eosinophils are bone marrow-derived granulocytes that are traditionally associated with
type 2 immune responses, such as those that occur during parasite infections and allergy …
type 2 immune responses, such as those that occur during parasite infections and allergy …
Entinostat in combination with nivolumab in metastatic pancreatic ductal adenocarcinoma: a phase 2 clinical trial
Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes,
abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI) …
abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI) …