Molecular mechanisms of Dicer: endonuclease and enzymatic activity
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …
pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA …
Plant dicer-like proteins: double-stranded RNA-cleaving enzymes for small RNA biogenesis
A Fukudome, T Fukuhara - Journal of Plant Research, 2017 - Springer
Dicer, a double-stranded RNA (dsRNA)-specific endoribonuclease, plays an essential role
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …
in triggering both transcriptional and post-transcriptional gene silencing in eukaryotes by …
Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex
S Yamaguchi, M Naganuma, T Nishizawa… - Nature, 2022 - nature.com
Abstract In flies, Argonaute2 (Ago2) and small interfering RNA (siRNA) form an RNA-
induced silencing complex to repress viral transcripts. The RNase III enzyme Dicer-2 …
induced silencing complex to repress viral transcripts. The RNase III enzyme Dicer-2 …
The molecular mechanism of microRNA duplex selectivity of Arabidopsis ARGONAUTE10
Abstract Small RNAs (sRNAs), including microRNAs (miRNAs) and small interfering RNAs
(siRNAs), are essential gene regulators for plant and animal development. The loading of …
(siRNAs), are essential gene regulators for plant and animal development. The loading of …
Dicer uses distinct modules for recognizing dsRNA termini
Invertebrates rely on Dicer to cleave viral double-stranded RNA (dsRNA), and Drosophila
Dicer-2 distinguishes dsRNA substrates by their termini. Blunt termini promote processive …
Dicer-2 distinguishes dsRNA substrates by their termini. Blunt termini promote processive …
A variety of dicer substrates in human and C. elegans
A Rybak-Wolf, M Jens, Y Murakawa, M Herzog… - Cell, 2014 - cell.com
The endoribonuclease Dicer is known for its central role in the biogenesis of eukaryotic
small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been …
small RNAs/microRNAs. Despite its importance, Dicer target transcripts have not been …
A glimpse of “Dicer Biology” through the structural and functional perspective
S Paturi, MV Deshmukh - Frontiers in molecular biosciences, 2021 - frontiersin.org
The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Dicer structure and function: conserved and evolving features
D Zapletal, K Kubicek, P Svoboda, R Stefl - EMBO reports, 2023 - embopress.org
RNase III Dicer produces small RNAs guiding sequence‐specific regulations, with important
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
biological roles in eukaryotes. Major Dicer‐dependent mechanisms are RNA interference …
RNA binding proteins in the miRNA pathway
P Connerty, A Ahadi, G Hutvagner - International journal of molecular …, 2015 - mdpi.com
microRNAs (miRNAs) are short~ 22 nucleotides (nt) ribonucleic acids which post-
transcriptionally regulate gene expression. miRNAs are key regulators of all cellular …
transcriptionally regulate gene expression. miRNAs are key regulators of all cellular …
Production of small RNAs by mammalian Dicer
E Svobodova, J Kubikova, P Svoboda - Pflügers Archiv-European Journal …, 2016 - Springer
MicroRNA (miRNA) and RNA interference (RNAi) pathways employ RNase III Dicer for the
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …
biogenesis of small RNAs guiding post-transcriptional repression. Requirements for Dicer …