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Achieving controlled biomolecule–biomaterial conjugation
The conjugation of biomolecules can impart materials with the bioactivity necessary to
modulate specific cell behaviors. While the biological roles of particular polypeptide …
modulate specific cell behaviors. While the biological roles of particular polypeptide …
[BOOK][B] Life in the Universe
D Schulze-Makuch, LN Irwin - 2004 - Springer
While grounded in the hard sciences of physics, chemistry, geology, and astronomy, as well
as well-accepted principles in the life sciences, astrobiology remains the most speculative of …
as well-accepted principles in the life sciences, astrobiology remains the most speculative of …
Making sense of “nonsense” and more: Challenges and opportunities in the genetic code expansion, in the world of tRNA modifications
The evolutional development of the RNA translation process that leads to protein synthesis
based on naturally occurring amino acids has its continuation via synthetic biology, the so …
based on naturally occurring amino acids has its continuation via synthetic biology, the so …
A visible and near-infrared light activatable diazocoumarin probe for fluorogenic protein labeling in living cells
SY Dai, D Yang - Journal of the American Chemical Society, 2020 - ACS Publications
Chemical modification of proteins in living cells permits valuable glimpses into the molecular
interactions that underpin dynamic cellular events. While genetic engineering methods are …
interactions that underpin dynamic cellular events. While genetic engineering methods are …
The optimality of the standard genetic code assessed by an eight-objective evolutionary algorithm
M Wnętrzak, P Błażej, D Mackiewicz… - BMC Evolutionary …, 2018 - Springer
Background The standard genetic code (SGC) is a unique set of rules which assign amino
acids to codons. Similar amino acids tend to have similar codons indicating that the code …
acids to codons. Similar amino acids tend to have similar codons indicating that the code …
Cell engineering and cultivation of Chinese hamster ovary cells for the development of orthogonal eukaryotic cell-free translation systems
JL Schloßhauer, N Cavak, A Zemella… - Frontiers in molecular …, 2022 - frontiersin.org
The investigation of protein structures, functions and interactions often requires
modifications to adapt protein properties to the specific application. Among many possible …
modifications to adapt protein properties to the specific application. Among many possible …
Engineering translation components for genetic code expansion
S Kim, H Yi, YT Kim, HS Lee - Journal of Molecular Biology, 2022 - Elsevier
The expansion of the genetic code consisting of four bases and 20 amino acids into diverse
building blocks has been an exciting topic in synthetic biology. Many biochemical …
building blocks has been an exciting topic in synthetic biology. Many biochemical …
Synthetic alienation of microbial organisms by using genetic code engineering: Why and how?
The main goal of synthetic biology (SB) is the creation of biodiversity applicable for
biotechnological needs, while xenobiology (XB) aims to expand the framework of natural …
biotechnological needs, while xenobiology (XB) aims to expand the framework of natural …
Solid-phase peptide capture and release for bulk and single-molecule proteomics
The field of proteomics has expanded recently with more sensitive techniques for the bulk
measurement of peptides as well as single-molecule techniques. One limiting factor for …
measurement of peptides as well as single-molecule techniques. One limiting factor for …
[HTML][HTML] Effects of heterologous tRNA modifications on the production of proteins containing noncanonical amino acids
Synthesis of proteins with noncanonical amino acids (ncAAs) enables the creation of protein-
based biomaterials with diverse new chemical properties that may be attractive for material …
based biomaterials with diverse new chemical properties that may be attractive for material …