Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

Eukaryotic transcription factors activate gene expression with their DNA-binding domains
and activation domains. DNA-binding domains bind the genome by recognizing structurally …

Transcriptional effectors are protein domains known to activate or repress gene expression;
however, a systematic understanding of which effector domains regulate transcription across …

Targeted epigenome editing tools allow precise manipulation and investigation of genome
modifications, however they often display high context dependency and variable efficacy …

Herpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA
sensing mechanisms to establish infection. The first viral latency protein expressed, EBNA …

Structure predictions have become invaluable tools for wet lab science by accelerating the
generation of structure-based hypotheses. While AlphaFold-predicted structures are …

To achieve exquisite control over the epigenome, we need a better predictive understanding
of how transcription factors, chromatin regulators, and their individual domain's function …

The advent of locus-specific protein recruitment technologies has enabled a new class of
studies in chromatin biology. Epigenome editors (EEs) enable biochemical modifications of …

Abstract The 7th International Conference on Epigenetics & Bioengineering held in
Amsterdam, The Netherlands was a successful event covering cutting-edge research …

RNA regulation plays an integral role in tuning gene expression and is controlled by
thousands of RNA-binding proteins (RBPs). We develop and use a high-throughput …