Circadian rhythm and disease: relationship, new insights, and future perspectives

AR Neves, T Albuquerque, T Quintela… - Journal of cellular …, 2022 - Wiley Online Library
The circadian system is responsible for internal functions and regulation of the organism
according to environmental cues (zeitgebers). Circadian rhythm dysregulation or …

[HTML][HTML] Molecular interactions between components of the circadian clock and the immune system

S Hergenhan, S Holtkamp, C Scheiermann - Journal of molecular biology, 2020 - Elsevier
The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

JO Early, D Menon, CA Wyse… - Proceedings of the …, 2018 - pnas.org
A variety of innate immune responses and functions are dependent on time of day, and
many inflammatory conditions are associated with dysfunctional molecular clocks within …

Asthma and obstructive sleep apnoea in adults and children–an up-to-date review

R Wang, S Mihaicuta, A Tiotiu, A Corlateanu… - Sleep Medicine …, 2022 - Elsevier
Obstructive sleep apnoea (OSA) and asthma are two common respiratory disorders in
children and adults. Apart from common risk factors, such as obesity, gastroesophageal …

[HTML][HTML] Time-of-day-dependent trafficking and function of leukocyte subsets

R Pick, W He, CS Chen, C Scheiermann - Trends in immunology, 2019 - cell.com
The number of leukocytes circulating in blood in mammals is under circadian control (ie,∼
24h). We summarize here latest findings on the mechanisms governing leukocyte migration …

Adaptive immunity, chronic inflammation and the clock

KJ Gray, JE Gibbs - Seminars in Immunopathology, 2022 - Springer
The adaptive arm of the immune system facilitates recognition of specific foreign pathogens
and, via the action of T and B lymphocytes, induces a fine-tuned response to target the …

Circadian molecular clock disruption in chronic pulmonary diseases

A Giri, Q Wang, I Rahman, IK Sundar - Trends in molecular medicine, 2022 - cell.com
The circadian clock is the biochemical oscillator with a near 24-h period that is responsible
for generating the circadian rhythms in peripheral organs including the lung. Mounting …

The evolutionary ecology of circadian rhythms in infection

ML Westwood, AJ O'Donnell, C de Bekker… - Nature ecology & …, 2019 - nature.com
Biological rhythms coordinate organisms' activities with daily rhythms in the environment.
For parasites, this includes rhythms in both the external abiotic environment and the within …

Brain response in asthma: the role of “lung-brain” axis mediated by neuroimmune crosstalk

Y Wang, YK Mou, HR Wang, XY Song, SZ Wei… - Frontiers in …, 2023 - frontiersin.org
In addition to typical respiratory symptoms, patients with asthma are frequently accompanied
by cognitive decline, mood disorders (anxiety and depression), sleep disorders, olfactory …

Circadian rhythms in adaptive immunity

P Downton, JO Early, JE Gibbs - Immunology, 2020 - Wiley Online Library
The circadian clock provides organisms with the ability to track time of day, allowing them to
predict and respond to cyclical changes in the external environment. In mammals this clock …