Among the different types of cytoskeletal components, microtubules arguably accumulate
the greatest diversity of post-translational modifications (PTMs). Acetylation of lysine 40 …

Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of
evolutionarily conserved α-tubulin–β-tubulin heterodimers. Despite their uniform structure …

Long-lived microtubules endow the eukaryotic cell with long-range transport abilities. While
long-lived microtubules are acetylated on Lys40 of α-tubulin (αK40), acetylation takes place …

Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT
cytoskeleton is considered to be a common insult during the pathogenesis of …

Microtubules are hollow tube-like polymeric structures composed of α, β-tubulin
heterodimers. They play an important role in numerous cellular processes, including …

Simple Summary Microtubules (MTs) are dynamic structures that compose part of the cell
cytoskeleton. They play important roles in various cellular functions, such as intracellular …

Acetylation is a well-studied post-translational modification (PTM) of tubulin. Acetylated
tubulin is present in the centrioles, primary cilia, and flagella, which contain long-lived stable …

Microtubules (MT) and actin microfilaments are dynamic cytoskeleton components involved
in a range of intracellular processes. MTs play a role in cell division, beating of cilia and …

Microtubules (MTs) mediate various cellular functions such as structural support,
chromosome segregation, and intracellular transport. To achieve this, the pivotal properties …

Bone is a mechano-responsive tissue that adapts to changes in its mechanical environment.
Increases in strain lead to increased bone mass acquisition, whereas decreases in strain …