Biomolecular condensates in contact with membranes

A Mangiarotti, R Dimova - Annual Review of Biophysics, 2024 - annualreviews.org
Biomolecular condensates are highly versatile membraneless organelles involved in a
plethora of cellular processes. Recent years have witnessed growing evidence of the …

Versatile phospholipid assemblies for functional synthetic cells and artificial tissues

X Wang, H Du, Z Wang, W Mu, X Han - Advanced Materials, 2021 - Wiley Online Library
The bottom‐up construction of a synthetic cell from nonliving building blocks capable of
mimicking cellular properties and behaviors helps to understand the particular biophysical …

Wetting regulates autophagy of phase-separated compartments and the cytosol

J Agudo-Canalejo, SW Schultz, H Chino, SM Migliano… - Nature, 2021 - nature.com
Compartmentalization of cellular material in droplet-like structures is a hallmark of liquid–
liquid phase separation,, but the mechanisms of droplet removal are poorly understood …

Kinetic control of shape deformations and membrane phase separation inside giant vesicles

WC Su, JCS Ho, DL Gettel, AT Rowland, CD Keating… - Nature Chemistry, 2024 - nature.com
A variety of cellular processes use liquid–liquid phase separation (LLPS) to create functional
levels of organization, but the kinetic pathways by which it proceeds remain incompletely …

Biomolecular condensates modulate membrane lipid packing and hydration

A Mangiarotti, M Siri, NW Tam, Z Zhao… - Nature …, 2023 - nature.com
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …

The 2018 biomembrane curvature and remodeling roadmap

P Bassereau, R **, T Baumgart… - Journal of physics D …, 2018 - iopscience.iop.org
The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …

Remodeling of membrane shape and topology by curvature elasticity and membrane tension

R Lipowsky - Advanced Biology, 2022 - Wiley Online Library
Cellular membranes exhibit a fascinating variety of different morphologies, which are
continuously remodeled by transformations of membrane shape and topology. This …

Giant vesicles and their use in assays for assessing membrane phase state, curvature, mechanics, and electrical properties

R Dimova - Annual review of biophysics, 2019 - annualreviews.org
Giant unilamellar vesicles represent a promising and extremely useful model biomembrane
system for systematic measurements of mechanical, thermodynamic, electrical, and …

Optimization of the inverted emulsion method for high‐yield production of biomimetic giant unilamellar vesicles

A Moga, N Yandrapalli, R Dimova… - ChemBioChem, 2019 - Wiley Online Library
In the field of bottom‐up synthetic biology, lipid vesicles provide an important role in the
construction of artificial cells. Giant unilamellar vesicles (GUVs), due to their membrane's …

The glycolipid GM1 reshapes asymmetric biomembranes and giant vesicles by curvature generation

R Dasgupta, MS Miettinen, N Fricke… - Proceedings of the …, 2018 - pnas.org
The ganglioside GM1 is present in neuronal membranes at elevated concentrations with an
asymmetric spatial distribution. It is known to generate curvature and can be expected to …