Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …

▪ Abstract DNA damage is a relatively common event in the life of a cell and may lead to
mutation, cancer, and cellular or organismic death. Damage to DNA induces several cellular …

Proliferating cell nuclear antigen (PCNA) was originally characterised as a DNA sliding
clamp for replicative DNA polymerases and as an essential component of the eukaryotic …

This review focuses on the biogenesis and composition of the eukaryotic DNA replication
fork, with an emphasis on the enzymes that synthesize DNA and repair discontinuities on the …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Processing of DNA in replication, repair and recombination pathways in cells of all
organisms requires the participation of at least one major single-stranded DNA (ssDNA) …

▪ Abstract Chromosomal DNA replicases are multicomponent machines that have evolved
clever strategies to perform their function. Although the structure of DNA is elegant in its …

To understand the mechanism of nucleotide excision repair (NER), one of the major human
DNA repair pathways, we have set up a DNA repair system in which a linear damaged DNA …

Replication protein A (RPA) is the main eukaryotic ssDNA-binding protein with essential
roles in DNA replication, recombination, and repair. RPA maintains the DNA as single …

The cellular pathways involved in maintaining genome stability halt cell cycle progression in
the presence of DNA damage or incomplete replication. Proteins required for this pathway …