Translation of acute ischemic stroke research to the clinical setting remains limited over the
last few decades with only one drug, recombinant tissue-type plasminogen activator …

Neuroinflammation underlies the etiology of multiple neurodegenerative diseases and
stroke. Our understanding of neuroinflammation has evolved in the last few years and major …

Ischemic stroke is a major cause of disability and mortality worldwide, but effective
restorative treatments are very limited at present. Regenerative medicine research revealed …

Recent evidence implicates cranial border immune compartments in the meninges, choroid
plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and …

Objective: Extracellular vesicles (EVs) derived from neural progenitor cells enhance
poststroke neurological recovery, albeit the underlying mechanisms remain elusive. Since …

Ischemic stroke initiates a robust inflammatory response that starts in the intravascular
compartment and involves rapid activation of brain resident cells. A key mechanism of this …

Local and systemic inflammation contribute significantly to stroke risk factors as well as
determining stroke impact and outcome. Previously being considered as an immuno …

Demyelination in vascular dementia (VD) is partly attributable to inflammation induced by
chronic cerebral hypoperfusion (CCH). Remyelination contributes to the recovery of …

Dendritic cells (DCs) are professional antigen presenting cells that constantly survey the
environment acting as sentinels of the immune system, including in the CNS. DCs are …

Stroke, including cerebral ischemia, intracerebral hemorrhage, and subarachnoid
hemorrhage, is the leading cause of long-term disability and death worldwide. Animal …