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New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry
K Bouchemal - Drug discovery today, 2008 - Elsevier
Long viewed as the 'method of choice'for characterizing thermodynamics and stoichiometry
of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been …
of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been …
How to conduct and interpret ITC experiments accurately for cyclodextrin–guest interactions
K Bouchemal, S Mazzaferro - Drug Discovery Today, 2012 - Elsevier
Isothermal titration calorimetry (ITC) is one of the most interesting methods for the
characterization of the interaction mechanisms of cyclodextrins (CDs) with drugs. In this …
characterization of the interaction mechanisms of cyclodextrins (CDs) with drugs. In this …
Synthesis and characterization of magnetite/PLGA/chitosan nanoparticles
In this work, we report the synthesis and characterization of a new hybrid nanoparticles
system performed by magnetite nanoparticles, loaded in a PLGA matrix, and stabilized by …
system performed by magnetite nanoparticles, loaded in a PLGA matrix, and stabilized by …
Dendrimer Platforms for Targeted Doxorubicin Delivery—Physicochemical Properties in Context of Biological Responses
M Szota, U Szwedowicz, N Rembialkowska… - International Journal of …, 2024 - mdpi.com
The unique structure of G4. 0 PAMAM dendrimers allows a drug to be enclosed in internal
spaces or immobilized on the surface. In the conducted research, the conditions for the …
spaces or immobilized on the surface. In the conducted research, the conditions for the …
[HTML][HTML] Pyrimidine derivatives as selective COX-2 inhibitors with anti-inflammatory and antioxidant properties
B Tylińska, A Janicka-Kłos… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Pyrimidine derivatives exhibit a wide range of biological activities, including anti-
inflammatory properties. The aim of this study was to investigate the effects of tested …
inflammatory properties. The aim of this study was to investigate the effects of tested …
2, 2′-Bipyridinebutyldithiocarbamatoplatinum (II) and palladium (II) complexes: synthesis, characterization, cytotoxicity, and rich DNA-binding studies
Butyldithiocarbamate sodium salt (Bu-dtcNa) and its two complexes,[M (bpy)(Bu-dtc)] NO3
(M= Pt (II) or Pd (II) and bpy= 2, 2′-bipyridine), have been synthesized and characterized …
(M= Pt (II) or Pd (II) and bpy= 2, 2′-bipyridine), have been synthesized and characterized …
Simultaneous determination of equilibrium constants and enthalpy changes by titration calorimetry: Methods, instruments, and uncertainties
LD Hansen, GW Fellingham, DJ Russell - Analytical biochemistry, 2011 - Elsevier
Calorimetric methods have been used to determine equilibrium constants since 1937, but no
comprehensive review of the various calorimeters and methods has been done previously …
comprehensive review of the various calorimeters and methods has been done previously …
Anticancer activity, DNA-binding and DNA-denaturing aptitude of palladium (II) dithiocarbamates
Although it is well known that cisplatin and its analogues are effective anticancer agents, but
their clinical use is restricted by some serious side effects. Palladium complexes are …
their clinical use is restricted by some serious side effects. Palladium complexes are …
DNA intercalation by quinacrine and methylene blue: a comparative binding and thermodynamic characterization study
There is compelling evidence that cellular DNA is the target of many anticancer agents.
Consequently, elucidation of the molecular nature governing the interaction of small …
Consequently, elucidation of the molecular nature governing the interaction of small …
Study on the interaction between active components from traditional Chinese medicine and plasma proteins
Q Jiao, R Wang, Y Jiang, B Liu - Chemistry Central Journal, 2018 - Springer
Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used
in Chinese traditional therapeutic systems over two thousand years. Active components in …
in Chinese traditional therapeutic systems over two thousand years. Active components in …