New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry

K Bouchemal - Drug discovery today, 2008 - Elsevier
Long viewed as the 'method of choice'for characterizing thermodynamics and stoichiometry
of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been …

How to conduct and interpret ITC experiments accurately for cyclodextrin–guest interactions

K Bouchemal, S Mazzaferro - Drug Discovery Today, 2012 - Elsevier
Isothermal titration calorimetry (ITC) is one of the most interesting methods for the
characterization of the interaction mechanisms of cyclodextrins (CDs) with drugs. In this …

Synthesis and characterization of magnetite/PLGA/chitosan nanoparticles

J Ibarra, J Melendres, M Almada… - Materials Research …, 2015 - iopscience.iop.org
In this work, we report the synthesis and characterization of a new hybrid nanoparticles
system performed by magnetite nanoparticles, loaded in a PLGA matrix, and stabilized by …

Dendrimer Platforms for Targeted Doxorubicin Delivery—Physicochemical Properties in Context of Biological Responses

M Szota, U Szwedowicz, N Rembialkowska… - International Journal of …, 2024 - mdpi.com
The unique structure of G4. 0 PAMAM dendrimers allows a drug to be enclosed in internal
spaces or immobilized on the surface. In the conducted research, the conditions for the …

[HTML][HTML] Pyrimidine derivatives as selective COX-2 inhibitors with anti-inflammatory and antioxidant properties

B Tylińska, A Janicka-Kłos… - International …, 2024 - pmc.ncbi.nlm.nih.gov
Pyrimidine derivatives exhibit a wide range of biological activities, including anti-
inflammatory properties. The aim of this study was to investigate the effects of tested …

2, 2′-Bipyridinebutyldithiocarbamatoplatinum (II) and palladium (II) complexes: synthesis, characterization, cytotoxicity, and rich DNA-binding studies

H Mansouri-Torshizi, I Mahboube, A Divsalar… - Bioorganic & medicinal …, 2008 - Elsevier
Butyldithiocarbamate sodium salt (Bu-dtcNa) and its two complexes,[M (bpy)(Bu-dtc)] NO3
(M= Pt (II) or Pd (II) and bpy= 2, 2′-bipyridine), have been synthesized and characterized …

Simultaneous determination of equilibrium constants and enthalpy changes by titration calorimetry: Methods, instruments, and uncertainties

LD Hansen, GW Fellingham, DJ Russell - Analytical biochemistry, 2011 - Elsevier
Calorimetric methods have been used to determine equilibrium constants since 1937, but no
comprehensive review of the various calorimeters and methods has been done previously …

Anticancer activity, DNA-binding and DNA-denaturing aptitude of palladium (II) dithiocarbamates

MK Amir, SZ Khan, F Hayat, A Hassan, IS Butler - Inorganica Chimica Acta, 2016 - Elsevier
Although it is well known that cisplatin and its analogues are effective anticancer agents, but
their clinical use is restricted by some serious side effects. Palladium complexes are …

DNA intercalation by quinacrine and methylene blue: a comparative binding and thermodynamic characterization study

M Hossain, P Giri, GS Kumar - DNA and Cell Biology, 2008 - liebertpub.com
There is compelling evidence that cellular DNA is the target of many anticancer agents.
Consequently, elucidation of the molecular nature governing the interaction of small …

Study on the interaction between active components from traditional Chinese medicine and plasma proteins

Q Jiao, R Wang, Y Jiang, B Liu - Chemistry Central Journal, 2018 - Springer
Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used
in Chinese traditional therapeutic systems over two thousand years. Active components in …