Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …
Function and regulation of SUMO proteases
Covalent attachment of small ubiquitin-like modifier (SUMO) to proteins is highly dynamic,
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …
and both SUMO–protein conjugation and cleavage can be regulated. Protein desumoylation …
Sumoylation: a regulatory protein modification in health and disease
A Flotho, F Melchior - Annual review of biochemistry, 2013 - annualreviews.org
Posttranslational modification with small ubiquitin-related modifier (SUMO) proteins is now
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …
established as one of the key regulatory protein modifications in eukaryotic cells. Hundreds …
SUMO-specific proteases and isopeptidases of the SENP family at a glance
K Kunz, T Piller, S Müller - Journal of cell science, 2018 - journals.biologists.com
The ubiquitin-related SUMO system controls many cellular signaling networks. In
mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent …
mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent …
SUMOylation-mediated regulation of cell cycle progression and cancer
K Eifler, ACO Vertegaal - Trends in biochemical sciences, 2015 - cell.com
Protein conjugation with Small ubiquitin-like modifier (SUMOylation) has critical roles during
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …
cell cycle progression. Many important cell cycle regulators, including many oncogenes and …
SUMO-specific proteases/isopeptidases: SENPs and beyond
SUMO-specific proteases/isopeptidases: SENPs and beyond | Genome Biology Skip to main
content SpringerLink Account Menu Find a journal Publish with us Track your research Search …
content SpringerLink Account Menu Find a journal Publish with us Track your research Search …
Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction
JM Henley, TJ Craig, KA Wilkinson - Physiological reviews, 2014 - journals.physiology.org
Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …
SENP3‐mediated deSUMOylation of dynamin‐related protein 1 promotes cell death following ischaemia
Global increases in small ubiquitin‐like modifier (SUMO)‐2/3 conjugation are a
neuroprotective response to severe stress but the mechanisms and specific target proteins …
neuroprotective response to severe stress but the mechanisms and specific target proteins …
SUMO 2 is essential while SUMO 3 is dispensable for mouse embryonic development
L Wang, C Wansleeben, S Zhao, P Miao… - EMBO …, 2014 - embopress.org
Small ubiquitin‐like modifier (SUMO 1–3) conjugation plays a critical role in embryogenesis.
Embryos deficient in the SUMO‐conjugating enzyme Ubc9 die at the early postimplantation …
Embryos deficient in the SUMO‐conjugating enzyme Ubc9 die at the early postimplantation …
Ubiquitin‐specific protease‐like 1 (USPL1) is a SUMO isopeptidase with essential, non‐catalytic functions
S Schulz, G Chachami, L Kozaczkiewicz, U Winter… - EMBO …, 2012 - embopress.org
Isopeptidases are essential regulators of protein ubiquitination and sumoylation. However,
only two families of SUMO isopeptidases are at present known. Here, we report an activity …
only two families of SUMO isopeptidases are at present known. Here, we report an activity …