Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …

Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …

The principal signals that drive memory and cognitive impairment in Alzheimer's disease
(AD) remain elusive. Here, we revealed brain-wide cellular reactions to type I interferon (IFN …

As the size of genome-wide association studies increase, the number of associated trait loci
identified inevitably increase. One welcomes this if it allows the better delineation of the …

Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of develo** Alzheimer's disease (AD). Whether and how …

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of
Alzheimer's disease, by its enrichment in transcriptional networks expressed by microglia …

The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …

Parkinson's disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ)
response in infections and to dopaminergic neuronal loss. However, whether and how …

Genome-wide association studies have reported that, amongst other microglial genes,
variants in TREM2 can profoundly increase the incidence of develo** Alzheimer's disease …

Alzheimer's disease (AD) is a spatially dynamic pathology that implicates a growing volume
of multiscale data spanning genetic, cellular, tissue, and organ levels of the organization …