[HTML][HTML] Difference between left-sided and right-sided colorectal cancer: a focused review of literature
Colorectal cancer is the third most common cancer worldwide with a high mortality rate at
the advanced stages. However, colorectal cancer is not a single type of tumor; its …
the advanced stages. However, colorectal cancer is not a single type of tumor; its …
Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
[HTML][HTML] Clinical-grade detection of microsatellite instability in colorectal tumors by deep learning
Background & Aims Microsatellite instability (MSI) and mismatch-repair deficiency (dMMR)
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …
in colorectal tumors are used to select treatment for patients. Deep learning can detect MSI …
Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …
Sexual dimorphism in colon cancer
M Abancens, V Bustos, H Harvey, J McBryan… - Frontiers in …, 2020 - frontiersin.org
A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
Young women (18–44 years) with CRC have a better survival outcome compared to men of …
The two faces of tumor-associated macrophages and their clinical significance in colorectal cancer
Macrophages are one of the immune populations frequently found in colorectal tumors and
high macrophage infiltration has been associated with both better and worst prognosis …
high macrophage infiltration has been associated with both better and worst prognosis …
Landscape of tumor mutation load, mismatch repair deficiency, and PD-L1 expression in a large patient cohort of gastrointestinal cancers
The efficacy of immunotherapy varies widely among different gastrointestinal cancers.
Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load …
Response to immune checkpoint inhibitors is shown to correlate with tumor mutation load …
Diagnosis and treatment of ERBB2-positive metastatic colorectal cancer: a review
Importance Amplification ofERBB2 (formerly referred to asHER2) is present in nearly 3% of
patients with metastatic colorectal cancer overall and 5% of patients …
patients with metastatic colorectal cancer overall and 5% of patients …
Immune escape and resistance to immunotherapy in mismatch repair deficient tumors
Up to 30% of colorectal, endometrial and gastric cancers have a deficiency in mismatch
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …
repair (MMR) protein expression due to either germline or epigenetic inactivation. Patients …
Recent trends in the age at diagnosis of colorectal cancer in the US National Cancer Data Base, 2004‐2015
Background The incidence of colorectal cancer (CRC) in adults younger than 50 years has
increased in the United States over the past decades according to Surveillance …
increased in the United States over the past decades according to Surveillance …