Skeletal muscle quantitative nuclear magnetic resonance imaging and spectroscopy as an outcome measure for clinical trials

PG Carlier, B Marty, O Scheidegger… - Journal of …, 2016‏ - journals.sagepub.com
Recent years have seen tremendous progress towards therapy of many previously incurable
neuromuscular diseases. This new context has acted as a driving force for the development …

Interleaved and simultaneous multi‐nuclear magnetic resonance in vivo. Review of principles, applications and potential

AL Lopez Kolkovsky, PG Carlier, B Marty… - NMR in …, 2022‏ - Wiley Online Library
Magnetic resonance signals from different nuclei can be excited or received at the same
time, rendering simultaneous or rapidly interleaved multi‐nuclear acquisitions feasible. The …

Skeletal muscle ATP synthesis and cellular H+ handling measured by localized 31P-MRS during exercise and recovery

GB Fiedler, AI Schmid, S Goluch, K Schewzow… - Scientific reports, 2016‏ - nature.com
Abstract 31P magnetic resonance spectroscopy (MRS) is widely used for non-invasive
investigation of muscle metabolism dynamics. This study aims to extend knowledge on …

Comparing localized and nonlocalized dynamic 31P magnetic resonance spectroscopy in exercising muscle at 7T

M Meyerspeer, S Robinson, CI Nabuurs… - Magnetic resonance …, 2012‏ - Wiley Online Library
By improving spatial and anatomical specificity, localized spectroscopy can enhance the
power and accuracy of the quantitative analysis of cellular metabolism and bioenergetics …

MITOCHONDRIA: investigation of in vivo muscle mitochondrial function by 31P magnetic resonance spectroscopy

JJ Prompers, B Wessels, GJ Kemp, K Nicolay - The international journal of …, 2014‏ - Elsevier
The most important function of mitochondria is the production of energy in the form of ATP.
The socio-economic impact of human diseases that affect skeletal muscle mitochondrial …

Localized semi-LASER dynamic 31P magnetic resonance spectroscopy of the soleus during and following exercise at 7 T

GB Fiedler, M Meyerspeer, AI Schmid, S Goluch… - … Resonance Materials in …, 2015‏ - Springer
Objectives This study demonstrates the applicability of semi-LASER localized dynamic 31 P
MRS to deeper lying areas of the exercising human soleus muscle (SOL). The effect of …

Combined MRI and 31P-MRS Investigations of the ACTA1(H40Y) Mouse Model of Nemaline Myopathy Show Impaired Muscle Function and Altered Energy …

C Gineste, Y Le Fur, C Vilmen, A Le Troter, E Pecchi… - PLoS …, 2013‏ - journals.plos.org
Nemaline myopathy (NM) is the most common disease entity among non-dystrophic skeletal
muscle congenital diseases. Mutations in the skeletal muscle α-actin gene (ACTA1) account …

Advanced noncontrast MR imaging in musculoskeletal radiology

S Partovi, H von Tengg-Kobligk… - Radiologic …, 2015‏ - radiologic.theclinics.com
The technique of skeletal muscle blood-oxygenlevel-dependent (BOLD) MR imaging has
been derived from functional MR imaging of the brain. In neuroimaging, the BOLD technique …

Noninvasive quantification of postocclusive reactive hyperemia in mouse thigh muscle by near-infrared diffuse correlation spectroscopy

R Cheng, X Zhang, A Daugherty, H Shin, G Yu - Applied optics, 2013‏ - opg.optica.org
Many vasculature-related diseases affecting skeletal muscle function have been studied in
mouse models. Noninvasive quantification of muscle blood flow responses during …

Repeatability assessment for simultaneous measurement of arterial blood flow, venous oxygen saturation, and muscle perfusion following dynamic exercise

SZ Mahmud, A Bashir - NMR in Biomedicine, 2023‏ - Wiley Online Library
The purpose of the present study was to demonstrate a new sequence and determine the
repeatability of simultaneous dynamic measurements of blood flow, venous oxygen …