Understanding the pathophysiology of depression: From monoamines to the neurogenesis hypothesis model-are we there yet?
A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
endocrine factors and neurogenesis) have been identified as mechanisms which provide …
Biomarkers for depression: recent insights, current challenges and future prospects
A plethora of research has implicated hundreds of putative biomarkers for depression, but
has not yet fully elucidated their roles in depressive illness or established what is abnormal …
has not yet fully elucidated their roles in depressive illness or established what is abnormal …
Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior
Accumulating evidence demonstrates that the gut microbiota affects brain function and
behavior, including depressive behavior. Antidepressants are the main drugs used for …
behavior, including depressive behavior. Antidepressants are the main drugs used for …
Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response
The role of serotonin in depression and antidepressant treatment remains unresolved
despite decades of research. In this paper, we make three major claims. First, serotonin …
despite decades of research. In this paper, we make three major claims. First, serotonin …
Cardiovascular disease and depression: A narrative review
X Li, J Zhou, M Wang, C Yang, G Sun - Frontiers in cardiovascular …, 2023 - frontiersin.org
In clinical practice, it is frequently observed that cardiac and psychological disorders
frequently co-occur, leading to the emergence of a field known as cardiovascular disease …
frequently co-occur, leading to the emergence of a field known as cardiovascular disease …
BDNF isoforms: a round trip ticket between neurogenesis and serotonin?
The brain‐derived neurotrophic factor, BDNF, was discovered more than 30 years ago and,
like other members of the neurotrophin family, this neuropeptide is synthetized as a …
like other members of the neurotrophin family, this neuropeptide is synthetized as a …
Serotonin and stress co**
S Puglisi-Allegra, D Andolina - Behavioural brain research, 2015 - Elsevier
Co** is the necessary outcome of any stressful situation and the major determinant of
stress resilience. Co** strategies can be divided into two broad categories, based on the …
stress resilience. Co** strategies can be divided into two broad categories, based on the …
5-HT2B receptors are required for serotonin-selective antidepressant actions
The therapeutic effects induced by serotonin-selective reuptake inhibitor (SSRI)
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …
antidepressants are initially triggered by blocking the serotonin transporter and rely on long …
Primum Non Nocere: An Evolutionary Analysis of Whether Antidepressants Do More Harm than Good
Antidepressant medications are the first-line treatment for people meeting current diagnostic
criteria for major depressive disorder. Most antidepressants are designed to perturb the …
criteria for major depressive disorder. Most antidepressants are designed to perturb the …
Serotonin reuptake inhibitors improve muscle stem cell function and muscle regeneration in male mice
M Fefeu, M Blatzer, A Kneppers, D Briand… - Nature …, 2024 - nature.com
Serotonin reuptake inhibitor antidepressants such as fluoxetine are widely used to treat
mood disorders. The mechanisms of action include an increase in extracellular level of …
mood disorders. The mechanisms of action include an increase in extracellular level of …