Metabolic engineering of the shikimate pathway for production of aromatics and derived compounds—present and future strain construction strategies

NJH Averesch, JO Krömer - Frontiers in Bioengineering and …, 2018 - frontiersin.org
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential
bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced …

Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products

M Cao, M Gao, M Suastegui, Y Mei, Z Shao - Metabolic engineering, 2020 - Elsevier
The aromatic amino acid biosynthesis pathway, together with its downstream branches,
represents one of the most commercially valuable biosynthetic pathways, producing a …

Light-driven fine chemical production in yeast biohybrids

J Guo, M Suástegui, KK Sakimoto, VM Moody, G **ao… - Science, 2018 - science.org
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Q Liu, T Yu, X Li, Y Chen, K Campbell, J Nielsen… - Nature …, 2019 - nature.com
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …

Remodelling metabolism for high-level resveratrol production in Yarrowia lipolytica

M Liu, C Wang, X Ren, S Gao, S Yu, J Zhou - Bioresource Technology, 2022 - Elsevier
Resveratrol is a polyphenol with numerous applications in food, pharma, and cosmetics.
Lack of precursors and low titer are the main problems hindering industrial scale resveratrol …

Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants

M Zhu, C Wang, W Sun, A Zhou, Y Wang, G Zhang… - Metabolic …, 2018 - Elsevier
Glycyrrhetinic acid (GA) and its precursor, 11-oxo-β-amyrin, are typical triterpenoids found in
the roots of licorice, a traditional Chinese medicinal herb that exhibits diverse functions and …

Multi‐modular engineering of Saccharomyces cerevisiae for high‐titre production of tyrosol and salidroside

H Liu, Y Tian, Y Zhou, Y Kan, T Wu… - Microbial …, 2021 - Wiley Online Library
Tyrosol and its glycosylated product salidroside are important ingredients in
pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces …

Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production

M Gao, Y Zhao, Z Yao, Q Su, P Van Beek… - Nature …, 2023 - nature.com
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with
broad applications. Here, we present the development of a yeast consortium for efficient …

Metabolic Engineering of Saccharomyces cerevisiae for De Novo Production of Kaempferol

X Lyu, G Zhao, KR Ng, R Mark… - Journal of agricultural …, 2019 - ACS Publications
Kaempferol is a polyphenolic compound with various reported health benefits and thus
harbors considerable potential for food-engineering applications. In this study, a high-yield …

Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors

M Suástegui, CY Ng, A Chowdhury, W Sun, M Cao… - Metabolic …, 2017 - Elsevier
A multilevel approach was implemented in Saccharomyces cerevisiae to optimize the
precursor module of the aromatic amino acid biosynthesis pathway, which is a rich resource …