Metabolic engineering of the shikimate pathway for production of aromatics and derived compounds—present and future strain construction strategies
The aromatic nature of shikimate pathway intermediates gives rise to a wealth of potential
bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced …
bio-replacements for commonly fossil fuel-derived aromatics, as well as naturally produced …
Building microbial factories for the production of aromatic amino acid pathway derivatives: from commodity chemicals to plant-sourced natural products
The aromatic amino acid biosynthesis pathway, together with its downstream branches,
represents one of the most commercially valuable biosynthetic pathways, producing a …
represents one of the most commercially valuable biosynthetic pathways, producing a …
Light-driven fine chemical production in yeast biohybrids
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …
cost-competitive and scalable approach to their production. However, microbial production …
Remodelling metabolism for high-level resveratrol production in Yarrowia lipolytica
M Liu, C Wang, X Ren, S Gao, S Yu, J Zhou - Bioresource Technology, 2022 - Elsevier
Resveratrol is a polyphenol with numerous applications in food, pharma, and cosmetics.
Lack of precursors and low titer are the main problems hindering industrial scale resveratrol …
Lack of precursors and low titer are the main problems hindering industrial scale resveratrol …
Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system from legume plants
Glycyrrhetinic acid (GA) and its precursor, 11-oxo-β-amyrin, are typical triterpenoids found in
the roots of licorice, a traditional Chinese medicinal herb that exhibits diverse functions and …
the roots of licorice, a traditional Chinese medicinal herb that exhibits diverse functions and …
Multi‐modular engineering of Saccharomyces cerevisiae for high‐titre production of tyrosol and salidroside
H Liu, Y Tian, Y Zhou, Y Kan, T Wu… - Microbial …, 2021 - Wiley Online Library
Tyrosol and its glycosylated product salidroside are important ingredients in
pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces …
pharmaceuticals, nutraceuticals and cosmetics. Despite the ability of Saccharomyces …
Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with
broad applications. Here, we present the development of a yeast consortium for efficient …
broad applications. Here, we present the development of a yeast consortium for efficient …
Metabolic Engineering of Saccharomyces cerevisiae for De Novo Production of Kaempferol
X Lyu, G Zhao, KR Ng, R Mark… - Journal of agricultural …, 2019 - ACS Publications
Kaempferol is a polyphenolic compound with various reported health benefits and thus
harbors considerable potential for food-engineering applications. In this study, a high-yield …
harbors considerable potential for food-engineering applications. In this study, a high-yield …
Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors
A multilevel approach was implemented in Saccharomyces cerevisiae to optimize the
precursor module of the aromatic amino acid biosynthesis pathway, which is a rich resource …
precursor module of the aromatic amino acid biosynthesis pathway, which is a rich resource …