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[HTML][HTML] Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …
for delivering amorphous drugs with poor water solubilities, and they have gained great …
[HTML][HTML] Continuous manufacturing of cocrystals using 3D-printed microfluidic chips coupled with spray coating
Using cocrystals has emerged as a promising strategy to improve the physicochemical
properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase …
properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase …
Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application …
Background The research was aimed with an approach to formulate biphasic extended-
release system of trospium chloride resulting in controlled release of drug up to 24 h with …
release system of trospium chloride resulting in controlled release of drug up to 24 h with …
Drug release from carrier systems comprising meloxicam crystals formed by impregnation-evaporation
P Zámostný, M Drahozal, O Švehla, S Römerová… - Crystals, 2023 - mdpi.com
The impregnation of poorly water-soluble drug onto the surface of a suitable pharmaceutical
excipient, used as a hydrophilic carrier, can lead to the preparation of systems with improved …
excipient, used as a hydrophilic carrier, can lead to the preparation of systems with improved …
[HTML][HTML] Dehydroepiandrosterone cocrystals with improved solubility and bioavailability
Y Jiang, Y Cheng, M **a, B Zhang, Q Ding, L Lu… - Pharmaceutics, 2022 - mdpi.com
Dehydroepiandrosterone (DHEA) is an FDA-approved food supplement used as an assisted
reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 …
reproductive sex hormone. The bioavailability is severely limited by its poor solubility (23 …
[HTML][HTML] Molecular Cocrystals with Hydrogen-Bonded Polymeric Structures and Polarized Luminescence
JY Zhao, FF Xu, ZQ Li, ZL Gong, YW Zhong, J Yao - Materials, 2022 - mdpi.com
Crystalline materials with appealing luminescent properties are attractive materials for
various optoelectronic applications. The in situ bicomponent reaction of 1, 2 …
various optoelectronic applications. The in situ bicomponent reaction of 1, 2 …
The effects of ascorbic acid and tartaric acid on pioglitazone hydrochloride solubility
Application of two coformers, l-tartaric acid (TA) and ascorbic acid (AA) was evaluated on the
solubility of pioglitazone hydrochloride (PGZ. HCl). Solid dispersions were prepared using …
solubility of pioglitazone hydrochloride (PGZ. HCl). Solid dispersions were prepared using …
[PDF][PDF] Development and evaluation of bicomponent cocrystals of aceclofenac for efficient drug delivery with enhanced solubility and improved dissolution
This research work was intended to improve the solubility and dissolution of aceclofenac by
the development of bicomponent cocrystals. Bicomponent cocrystals of aceclofenac were …
the development of bicomponent cocrystals. Bicomponent cocrystals of aceclofenac were …
Development and pharmacokinetic evaluation of osmotically controlled drug delivery system of Valganciclovir HCl for potential application in the treatment of CMV …
Valganciclovir HCl (VGH) is the widely used drug for the treatment of cytomegalovirus (CMV)
retinitis infection with an induction dose of 900 mg per oral (po) twice a day and a …
retinitis infection with an induction dose of 900 mg per oral (po) twice a day and a …
Development and evaluation of drug-cyclodextrin-polymer ternary system of Cefuroxime axetil to enhance the solubility and dissolution efficiency
AT Jadhav, KB Burade, DA Kulkarni… - Research Journal of …, 2022 - indianjournals.com
Cefuroxime axetil (CA) is BCS class II drug and has 55% absolute oral bioavailability due to
poor aqueous solubility hence the present work is an attempt to enhance the solubility and …
poor aqueous solubility hence the present work is an attempt to enhance the solubility and …