Cell competition in development, homeostasis and cancer
SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …
that collectively regulate tissue architecture and function. To ensure the highest tissue …
Impact of risk factors on early cancer evolution
Recent identification of oncogenic cells within healthy tissues and the prevalence of indolent
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
cancers found incidentally at autopsies reveal a greater complexity in tumor initiation than …
Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer
The consensus molecular subtype (CMS) classification of colorectal cancer is based on bulk
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
transcriptomics. The underlying epithelial cell diversity remains unclear. We analyzed …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …
of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT …
Cell competition in intratumoral and tumor microenvironment interactions
TM Parker, K Gupta, AM Palma, M Yekelchyk… - The EMBO …, 2021 - embopress.org
Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition
The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
Hallmarks of stemness in mammalian tissues
All adult tissues experience wear and tear. Most tissues can compensate for cell loss
through the activity of resident stem cells. Although the cellular maintenance strategies vary …
through the activity of resident stem cells. Although the cellular maintenance strategies vary …
BNIP3-mediated mitophagy boosts the competitive growth of Lenvatinib-resistant cells via energy metabolism reprogramming in HCC
S Wang, H Cheng, M Li, D Gao, H Wu, S Zhang… - Cell Death & …, 2024 - nature.com
An increasing evidence supports that cell competition, a vital selection and quality control
mechanism in multicellular organisms, is involved in tumorigenesis and development; …
mechanism in multicellular organisms, is involved in tumorigenesis and development; …
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …
are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal …