Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

The sphingomyelin (SM) cycle is an emerging pathway of signal transduction that plays a
role in the control of cell growth, cell differentiation, and apoptosis. During earlier …

Background Identification of robust biomarkers of malignancy and methods to establish
disease progression is a major goal in paediatric neuro-oncology. We investigated whether …

Background Histopathological grading of ependymoma has been controversial with respect
to its reproducibility and clinical significance. In a 3-phase study, we reviewed the pathology …

Purpose The biologic behavior of intracranial ependymoma is unpredictable on the basis of
current staging approaches. We aimed at the identification of recurrent genetic aberrations …

Patients with ependymoma exhibit a wide range of clinical outcomes that are currently
unexplained by clinical or histological factors. Little is known regarding molecular …

Ependymoma is the third most common brain tumor in children, but there is a paucity of
large studies with more than 10 years of follow-up examining the long-term survival and …

Telomerase activation is critical in many cancers including central nervous system (CNS)
tumors. Imetelstat is an oligonucleotide that binds to the template region of the RNA …

Brain tumors are the most common solid tumors in children. With the increasingly
widespread availability of MRI, the incidence of childhood brain tumors seemed to rise in the …

Purpose: The high incidence of recurrence and unpredictable clinical outcome for pediatric
ependymoma reflect the imprecision of current therapeutic staging and need for novel risk …