The role and therapeutic potential of itaconate in lung disease

R He, Y Zuo, K Yi, B Liu, C Song, N Li… - Cellular & Molecular …, 2024 - Springer
Lung diseases triggered by endogenous or exogenous factors have become a major
concern, with high morbidity and mortality rates, especially after the coronavirus disease …

[HTML][HTML] Harnessing immunity: Immunomodulatory therapies in COVID-19

T Velikova, H Valkov, A Aleksandrova… - World Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
An overly exuberant immune response, characterized by a cytokine storm and uncontrolled
inflammation, has been identified as a significant driver of severe coronavirus disease 2019 …

Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA. 1 infection of K18-hACE2 mice

A Carolin, K Yan, CR Bishop, B Tang, W Nguyen… - Plos one, 2024 - journals.plos.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus
Disease 2019 (COVID-19), which can result in severe disease, often characterised by a …

The mRNA-LNP vaccines–the good, the bad and the ugly?

BZ Igyártó, Z Qin - Frontiers in Immunology, 2024 - frontiersin.org
The mRNA-LNP vaccine has received much attention during the COVID-19 pandemic since
it served as the basis of the most widely used SARS-CoV-2 vaccines in Western countries …

Using a static magnetic field to attenuate the severity in COVID-19-invaded lungs

HY Lai, KC Fan, YH Lee, WZ Lew, WY Lai, SY Lee… - Scientific Reports, 2024 - nature.com
Two important factors affecting the progress of coronavirus disease 2019 (COVID-19)
caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are the S …

Bronchoalveolar lavage single-cell transcriptomics reveals immune dysregulations driving COVID-19 severity

CN Asaba, R Bitazar, P Labonté, TN Bukong - PloS one, 2025 - journals.plos.org
The continuous threats posed by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2), the virus that causes COVID-19, including the emergence of potentially more …

COVID-19: A threat to the respiratory system

G Rasool, WA Khan, AM Khan, M Riaz… - International …, 2024 - journals.sagepub.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes acute
coronavirus disease-19 (COVID-19) that has emerged on a pandemic level. Coronaviruses …

[HTML][HTML] Multidrug Combinations against SARS-CoV-2 Using GS-441524 or Ivermectin with Molnupiravir and/or Nirmatrelvir in Reconstituted Human Nasal Airway …

D Siegrist, HR Jonsdottir, M Bouveret, B Boda… - Pharmaceutics, 2024 - mdpi.com
Background. The emergence, global spread, and persistence of SARS-CoV-2 resulted in an
unprecedented need for effective antiviral drugs. Throughout the pandemic, various drug …

IL‐37 possesses both anti‐inflammatory and antiviral effects against Middle East respiratory syndrome coronavirus infection

F Qi, Y Yan, Q Lv, M Liu, M Liu, F Li… - Animal Models and …, 2024 - Wiley Online Library
Background The aim was to elucidate the function of IL‐37 in middle east respiratory
syndrome coronavirus (MERS‐CoV) infection, thereby providing a novel therapeutic strategy …

Antiviral effectiveness and safety of azvudine in hospitalized SARS‐CoV‐2 patients with pre‐existing chronic respiratory diseases: A multicenter, retrospective cohort …

J Sun, M Yang, D Yao, Y Zhou, X Hu, G Qian, Y Yuan… - View, 2025 - Wiley Online Library
Although azvudine has become a priority in the treatment of SARS‐CoV‐2, its effectiveness
and safety among COVID‐19 patients who already have chronic respiratory diseases …