Abstract Ethnopharmacological relevance Astragali Radix (AR, Huangqi in Chinese), the
dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or A …

Astragalus membranaceus (Fisch) Bge (Huang-Qi) is a well-known herbal medicine with
tonic property and has been widely used to treat cancer and other immune disorders in …

Astragali Radix (AR), a Chinese materia medica (CMM) known as Huangqi, is an important
medicine prescribed in herbal composite formulae (Fufang) by Traditional Chinese medicine …

Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central
nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal …

Background: Neurological disorders constitute a growing worldwide concern due to the
progressive aging of the population and the risky behavior they represent. Herbal medicines …

Diabetic peripheral neuropathy (DPN) is one of the most prevalent consequences of
diabetes, with a high incidence and disability rate. The DPN's pathogenesis is extremely …

Background Microglia-mediated neuroinflammation is one of the most prominent
characteristics of multiple sclerosis (MS), a chronic demyelination disease. As one of the …

Abstract Ethnopharmacological relevance Radix Astragali is a traditional Chinese medicine
with various pharmacological effects. Total astragalosides (TA), the main effective …

Inhibition of microglia activation may provide therapeutic treatment for many
neurodegenerative diseases. Astragaloside IV (ASI) with anti-inflammatory properties has …

Stressed oligodendrocytes (OLGs) activate microglia to produce an inflammatory response,
and the impairment of mitochondria further aggravates OLG damage, which is the earliest …